TY - JOUR
T1 - Cytogenetic and molecular genetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation
AU - Macarenco, Ricardo S.
AU - Erickson-Johnson, Michele
AU - Wang, Xiaoke
AU - Jenkins, Robert B.
AU - Nascimento, Antonio G.
AU - Oliveira, Andre M.
N1 - Funding Information:
R.S.M. is a visiting clinician at the Department of Anatomic Pathology from CIPAX–Unidade de Patologia Cirúrgica e Citopatologia de São José dos Campos (SP), Brazil. Editing, proofreading, and reference verification were provided by the Section of Scientific Publications, Mayo Clinic. This work was supported by grants from the Mayo Clinic Foundation CR20 Award (14546) and Fraternal Order of Eagles Foundation award (RRF20J).
PY - 2006/12
Y1 - 2006/12
N2 - Dedifferentiated liposarcoma, a subtype of liposarcoma, is characterized by juxtaposition of well-differentiated liposarcoma with a nonadipocytic sarcoma. A peculiar form of dedifferentiated liposarcoma has been described, characterized by a nonlipogenic component with a neural-like whorling pattern of growth and metaplastic bone formation. We report the cytogenetic and molecular genetic findings of this peculiar form of dedifferentiation in a retroperitoneal tumor found in a 58-year-old woman. The neoplasm had the typical histologic findings and a complex karyotype characterized by several numeric and structural chromosome abnormalities, including the presence of ring and giant rod chromosomes. Molecular genetic studies found high levels of amplification of the MDM2 oncogene, consistent with the amplification of the 12q14 chromosome band, a cytogenetic abnormality commonly found in these tumors. These findings indicate that, despite its unique and peculiar morphologic features, this unusual type of dedifferentiated liposarcoma shares many of the cytogenetic and molecular genetic abnormalities found in other forms of dedifferentiation. However, the specific cytogenetic and molecular determinants of these peculiar morphologic findings remain unknown.
AB - Dedifferentiated liposarcoma, a subtype of liposarcoma, is characterized by juxtaposition of well-differentiated liposarcoma with a nonadipocytic sarcoma. A peculiar form of dedifferentiated liposarcoma has been described, characterized by a nonlipogenic component with a neural-like whorling pattern of growth and metaplastic bone formation. We report the cytogenetic and molecular genetic findings of this peculiar form of dedifferentiation in a retroperitoneal tumor found in a 58-year-old woman. The neoplasm had the typical histologic findings and a complex karyotype characterized by several numeric and structural chromosome abnormalities, including the presence of ring and giant rod chromosomes. Molecular genetic studies found high levels of amplification of the MDM2 oncogene, consistent with the amplification of the 12q14 chromosome band, a cytogenetic abnormality commonly found in these tumors. These findings indicate that, despite its unique and peculiar morphologic features, this unusual type of dedifferentiated liposarcoma shares many of the cytogenetic and molecular genetic abnormalities found in other forms of dedifferentiation. However, the specific cytogenetic and molecular determinants of these peculiar morphologic findings remain unknown.
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U2 - 10.1016/j.cancergencyto.2006.07.009
DO - 10.1016/j.cancergencyto.2006.07.009
M3 - Article
C2 - 17116493
AN - SCOPUS:33750972278
SN - 0165-4608
VL - 171
SP - 126
EP - 129
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -