Cytogenetic abnormalities in MGUS and myeloma

Rafael Fonseca; P. Leif Bergsagel; W. Michael Kuehl

doi:10.1007/978-1-4614-3764-2_30

Cytogenetic abnormalities in MGUS and myeloma

Rafael Fonseca, P. Leif Bergsagel, W. Michael Kuehl

Hematology/Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

There is clear evidence that chromosomal abnormalities play a major role in the pathogenesis and progression of multiple myeloma (MM). MM can be divided into two major subcategories: hyperdiploid MM (H-MM) which is composed of cases with multiple trisomies of the odd numbered chromosomes and non-hyperdiploid MM (NH-MM) which is characterized by translocations of the IgH locus. Specific cytogenetic abnormalities predict the clinical outcome of patients. Determination of the common cytogenetic aberrations is an integral part of MM patients' clinical evaluation.

Original language	English (US)
Title of host publication	Neoplastic Diseases of the Blood
Publisher	Springer New York
Pages	589-599
Number of pages	11
ISBN (Electronic)	9781461437642
ISBN (Print)	1461437636, 9781461437635
DOIs	https://doi.org/10.1007/978-1-4614-3764-2_30
State	Published - Nov 1 2013

Keywords

Monoclonal gammopathy of undetermined significance cytogenetics
Multiple myeloma cytogenetics
Translocations

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-3764-2_30

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N2 - There is clear evidence that chromosomal abnormalities play a major role in the pathogenesis and progression of multiple myeloma (MM). MM can be divided into two major subcategories: hyperdiploid MM (H-MM) which is composed of cases with multiple trisomies of the odd numbered chromosomes and non-hyperdiploid MM (NH-MM) which is characterized by translocations of the IgH locus. Specific cytogenetic abnormalities predict the clinical outcome of patients. Determination of the common cytogenetic aberrations is an integral part of MM patients' clinical evaluation.

AB - There is clear evidence that chromosomal abnormalities play a major role in the pathogenesis and progression of multiple myeloma (MM). MM can be divided into two major subcategories: hyperdiploid MM (H-MM) which is composed of cases with multiple trisomies of the odd numbered chromosomes and non-hyperdiploid MM (NH-MM) which is characterized by translocations of the IgH locus. Specific cytogenetic abnormalities predict the clinical outcome of patients. Determination of the common cytogenetic aberrations is an integral part of MM patients' clinical evaluation.

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KW - Multiple myeloma cytogenetics

KW - Translocations

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BT - Neoplastic Diseases of the Blood

PB - Springer New York

ER -

Cytogenetic abnormalities in MGUS and myeloma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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