Cytogenetic abnormalities in MGUS and myeloma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is clear evidence that chromosomal abnormalities play a major role in the pathogenesis and progression of multiple myeloma (MM). MM can be divided into two major subcategories: hyperdiploid MM (H-MM) which is composed of cases with multiple trisomies of the odd numbered chromosomes and non-hyperdiploid MM (NH-MM) which is characterized by translocations of the IgH locus. Specific cytogenetic abnormalities predict the clinical outcome of patients. Determination of the common cytogenetic aberrations is an integral part of MM patients' clinical evaluation.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Pages589-599
Number of pages11
ISBN (Print)9781461437642, 1461437636, 9781461437635
DOIs
StatePublished - Nov 1 2013

Keywords

  • Monoclonal gammopathy of undetermined significance cytogenetics
  • Multiple myeloma cytogenetics
  • Translocations

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Fonseca, R., Bergsagel, P. L., & Kuehl, W. M. (2013). Cytogenetic abnormalities in MGUS and myeloma. In Neoplastic Diseases of the Blood (pp. 589-599). Springer New York. https://doi.org/10.1007/978-1-4614-3764-2_30