There is clear evidence that chromosomal abnormalities play a major role in the pathogenesis and progression of multiple myeloma (MM). MM can be divided into two major subcategories: hyperdiploid MM (H-MM) which is composed of cases with multiple trisomies of the odd numbered chromosomes and non-hyperdiploid MM (NH-MM) which is characterized by translocations of the IgH locus. Specific cytogenetic abnormalities predict the clinical outcome of patients. Determination of the common cytogenetic aberrations is an integral part of MM patients' clinical evaluation.
- Monoclonal gammopathy of undetermined significance cytogenetics
- Multiple myeloma cytogenetics
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