Cyclosporine in Primary Biliary Cirrhosis

Santiago J. Munoz, Russell H. Wiesner, Jurgen Ludwig, Keith D. Lindor, Roberta A. Jorgensen, William P. Baldus, Henry A. Homburger, E. Rolland Dickson

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume323
Issue number19
DOIs
StatePublished - Nov 8 1990

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Biliary Liver Cirrhosis
Cyclosporine
Hypertrichosis
Gingiva
Tremor
Double-Blind Method
Hyperplasia
Creatinine
Arterial Pressure
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Munoz, S. J., Wiesner, R. H., Ludwig, J., Lindor, K. D., Jorgensen, R. A., Baldus, W. P., ... Dickson, E. R. (1990). Cyclosporine in Primary Biliary Cirrhosis. New England Journal of Medicine, 323(19). https://doi.org/10.1056/NEJM199011083231916

Cyclosporine in Primary Biliary Cirrhosis. / Munoz, Santiago J.; Wiesner, Russell H.; Ludwig, Jurgen; Lindor, Keith D.; Jorgensen, Roberta A.; Baldus, William P.; Homburger, Henry A.; Dickson, E. Rolland.

In: New England Journal of Medicine, Vol. 323, No. 19, 08.11.1990.

Research output: Contribution to journalLetter

Munoz, SJ, Wiesner, RH, Ludwig, J, Lindor, KD, Jorgensen, RA, Baldus, WP, Homburger, HA & Dickson, ER 1990, 'Cyclosporine in Primary Biliary Cirrhosis', New England Journal of Medicine, vol. 323, no. 19. https://doi.org/10.1056/NEJM199011083231916
Munoz SJ, Wiesner RH, Ludwig J, Lindor KD, Jorgensen RA, Baldus WP et al. Cyclosporine in Primary Biliary Cirrhosis. New England Journal of Medicine. 1990 Nov 8;323(19). https://doi.org/10.1056/NEJM199011083231916
Munoz, Santiago J. ; Wiesner, Russell H. ; Ludwig, Jurgen ; Lindor, Keith D. ; Jorgensen, Roberta A. ; Baldus, William P. ; Homburger, Henry A. ; Dickson, E. Rolland. / Cyclosporine in Primary Biliary Cirrhosis. In: New England Journal of Medicine. 1990 ; Vol. 323, No. 19.
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