Cyclosporine in Primary Biliary Cirrhosis

Santiago J. Munoz; Russell H. Wiesner; Jurgen Ludwig; Keith D. Lindor; Roberta A. Jorgensen; William P. Baldus; Henry A. Homburger; E. Rolland Dickson

doi:10.1056/NEJM199011083231916

Cyclosporine in Primary Biliary Cirrhosis

Santiago J. Munoz, Russell H. Wiesner, Jurgen Ludwig, Keith D. Lindor, Roberta A. Jorgensen, William P. Baldus, Henry A. Homburger, E. Rolland Dickson

Gastroenterology and Hepatology

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…

Original language	English (US)
Pages (from-to)	1352
Number of pages	1
Journal	New England Journal of Medicine
Volume	323
Issue number	19
DOIs	https://doi.org/10.1056/NEJM199011083231916
State	Published - Nov 8 1990

ASJC Scopus subject areas

Medicine(all)

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title = "Cyclosporine in Primary Biliary Cirrhosis",

abstract = "To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…",

author = "Munoz, {Santiago J.} and Wiesner, {Russell H.} and Jurgen Ludwig and Lindor, {Keith D.} and Jorgensen, {Roberta A.} and Baldus, {William P.} and Homburger, {Henry A.} and Dickson, {E. Rolland}",

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T1 - Cyclosporine in Primary Biliary Cirrhosis

AU - Munoz, Santiago J.

AU - Wiesner, Russell H.

AU - Ludwig, Jurgen

AU - Lindor, Keith D.

AU - Jorgensen, Roberta A.

AU - Baldus, William P.

AU - Homburger, Henry A.

AU - Dickson, E. Rolland

PY - 1990/11/8

Y1 - 1990/11/8

N2 - To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…

AB - To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…

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Cyclosporine in Primary Biliary Cirrhosis

Abstract

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