Cyclosporine in Primary Biliary Cirrhosis

Santiago J. Munoz, Russell H. Wiesner, Jurgen Ludwig, Keith D. Lindor, Roberta A. Jorgensen, William P. Baldus, Henry A. Homburger, E. Rolland Dickson

Research output: Contribution to journalLetter

1 Scopus citations

Abstract

To the Editor: Wiesner et al. are to be congratulated for their innovative study on the use of cyclosporine in early primary biliary cirrhosis (May 17 issue).* However, it is important to point out that although the authors claim that this was a double-blind protocol, the study was not rigorously blinded. Even at low dosages, cyclosporine leads to a significant and noticeable elevation in the arterial blood pressure and serum creatinine level. Hypertrichosis, tremors, and gum hyperplasia also develop in many patients. These features are readily perceived by the patients themselves. In the study by Wiesner et al., 15 of…

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume323
Issue number19
DOIs
StatePublished - Nov 8 1990

ASJC Scopus subject areas

  • Medicine(all)

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    Munoz, S. J., Wiesner, R. H., Ludwig, J., Lindor, K. D., Jorgensen, R. A., Baldus, W. P., Homburger, H. A., & Dickson, E. R. (1990). Cyclosporine in Primary Biliary Cirrhosis. New England Journal of Medicine, 323(19). https://doi.org/10.1056/NEJM199011083231916