Cyclosporine A alleviates severe anaemia associated with refractory large granular lymphocytic leukaemia and chronic natural killer cell lymphocytosis

Keith C. Bible, Ayalew Tefferi

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Large granular lymphocytic (LGL) leukaemia and chronic natural killer cell lymphocytosis (CNKL) are chronic indolent disorders often associated with neutropenia and constitutional symptoms. Severe anaemia occurs in about 20% of patients and is currently treated with corticosteroids followed by oral cyclophosphamide in non-responders. 30% of patients fail initial measures, and salvage therapy is inadequate. We describe three transfusion-dependent patients (two with T-LGL leukaemia, one with CNKL) refractory to corticosteroids, cyclophosphamide, and in one case fludarabine. Cyclosporine A (CSA) initiation resulted in prompt transfusion-independence and was well tolerated in all patients, making it an attractive alternative therapy for this disorder.

Original languageEnglish (US)
Pages (from-to)406-408
Number of pages3
JournalBritish journal of haematology
Volume93
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • cyclosporine A
  • large granular lymphocytic leukaemia
  • natural killer cell lymphocytosis
  • severe anaemia
  • treatment

ASJC Scopus subject areas

  • Hematology

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