Cyclosporin A enhances T cell‐mediated induction of E‐selectin

Ahmet Doǧan, Thomas T. MacDonald, Jo Spencer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In a fetal intestinal organ culture model of intestinal inflammation, activation of T cells by a lectin, superantigen or anti‐CD3 antibodies induces E‐selectin expression which peaks 6‐10 h after activation and disappears by 24 h. We now show that addition of cyclosporin A (Cys A) increases the number of E‐selectin‐expressing endothelial cells and the intensity of expression, and it prolongs expression up to at least 60 h after stimulation. The dynamics of E‐selectin expression on tumor necrosis factor activated human umbilical‐vein endothelial cell cultures is not affected by Cys A. Furthermore, other immunosuppressive agents FK 506 and dexamethasone inhibit E‐selectin expression, indicating that the enhancement observed in the presence of Cys A is not a consequence of general immunosuppression.

Original languageEnglish (US)
Pages (from-to)2922-2926
Number of pages5
JournalEuropean Journal of Immunology
Volume23
Issue number11
DOIs
StatePublished - Nov 1993
Externally publishedYes

Keywords

  • Cyclosporin A
  • E‐selectin
  • Intestine
  • Tcell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Cyclosporin A enhances T cell‐mediated induction of E‐selectin'. Together they form a unique fingerprint.

  • Cite this