Cyclophosphamide-Induced Hepatotoxicity in a Patient With Wegener's Granulomatosis

LINDA S. SNYDER; RUSSELL I. HEIGH; MONTE L. ANDERSON

doi:10.1016/S0025-6196(12)60074-3

Cyclophosphamide-Induced Hepatotoxicity in a Patient With Wegener's Granulomatosis

LINDA S. SNYDER, RUSSELL I. HEIGH, MONTE L. ANDERSON

Gastroenterology and Hepatology

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25 Scopus citations

Abstract

Cyclophosphamide is widely used in the treatment of many vasculitides. Hepatotoxicity associated with such therapy is uncommon but possible. Herein we describe a well-substantiated case of cyclophosphamide-induced hepatotoxicity in a patient with Wegener's granulomatosis. Physicians should be aware of this potentially serious reaction when cyclophosphamide therapy is initiated. Baseline liver function tests and periodic assessment are recommended during treatment with cyclophosphamide.

Original language	English (US)
Pages (from-to)	1203-1204
Number of pages	2
Journal	Mayo Clinic proceedings
Volume	68
Issue number	12
DOIs	https://doi.org/10.1016/S0025-6196(12)60074-3
State	Published - 1993

ASJC Scopus subject areas

General Medicine

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10.1016/S0025-6196(12)60074-3

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abstract = "Cyclophosphamide is widely used in the treatment of many vasculitides. Hepatotoxicity associated with such therapy is uncommon but possible. Herein we describe a well-substantiated case of cyclophosphamide-induced hepatotoxicity in a patient with Wegener's granulomatosis. Physicians should be aware of this potentially serious reaction when cyclophosphamide therapy is initiated. Baseline liver function tests and periodic assessment are recommended during treatment with cyclophosphamide.",

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AB - Cyclophosphamide is widely used in the treatment of many vasculitides. Hepatotoxicity associated with such therapy is uncommon but possible. Herein we describe a well-substantiated case of cyclophosphamide-induced hepatotoxicity in a patient with Wegener's granulomatosis. Physicians should be aware of this potentially serious reaction when cyclophosphamide therapy is initiated. Baseline liver function tests and periodic assessment are recommended during treatment with cyclophosphamide.

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Cyclophosphamide-Induced Hepatotoxicity in a Patient With Wegener's Granulomatosis

Abstract

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