Abstract
A phase II study of cyclophosphamide, cisplatin, and leuprolide acetate after debulking of stage III or IV ovarian carcinoma was conducted in 33 patients through a cooperative group study involving 11 institutions. The intent was to determine whether the addition of a gonadotropin-releasing hormone analogue would alter the response rates and toxicity profile of cyclophosphamide and cisplatin in patients with advanced ovarian cancer. Twenty-nine patients completed all 6 planned cycles. Of the 19 patients who had second-look laparotomy, 12 had persistent disease and 7 were negative for disease. The use of a gonadotropin-releasing hormone with combined chemotherapy did not alter the toxicity profile or the effectiveness of chemotherapy when comparisons were made with historical controls.
Original language | English (US) |
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Pages (from-to) | 196-200 |
Number of pages | 5 |
Journal | Gynecologic oncology |
Volume | 54 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1994 |
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology