Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing

Chunjie Sheng, Chen Yao, Ziyang Wang, Hongyuan Chen, Yu Zhao, Dazhi Xu, Haojie Huang, Wenlin Huang, Shuai Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing is reported to function in the nuclear factor-kappa B (NF-κB) signal pathway, but the regulatory mechanism remains elusive. Here we show that cyclophilin J (CYPJ), a member of the peptidylprolyl isomerase family, is induced by inflammation. CYPJ interacts with the NZF domain of transform growth factor-β activated kinase 1 binding protein 2 and 3 as well as components of the linear ubiquitin chain assembly complex to block the binding of ubiquitin-chain and negatively regulates NF-κB signaling. Mice with Cypj deficiency are susceptible to lipopolysaccharide and heat-killed Listeria monocytogenes-induced sepsis and dextran sulfate sodium-induced colitis. These findings identify CYPJ as a negative feedback regulator of the NF-κB signaling pathway, and provide insights for understanding the homeostasis of innate immunity.

Original languageEnglish (US)
Article number4381
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint

Cyclophilins
NF-kappa B
Ubiquitin
Zinc Fingers
Inflammation
homeostasis
Zinc
Homeostasis
Peptidylprolyl Isomerase
Listeria
Dextran Sulfate
zinc
Listeria monocytogenes
Colitis
Innate Immunity
negative feedback
dextrans
Lipopolysaccharides
Signal Transduction
regulators

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Sheng, C., Yao, C., Wang, Z., Chen, H., Zhao, Y., Xu, D., ... Chen, S. (2018). Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Nature Communications, 9(1), [4381]. https://doi.org/10.1038/s41467-018-06756-3

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. / Sheng, Chunjie; Yao, Chen; Wang, Ziyang; Chen, Hongyuan; Zhao, Yu; Xu, Dazhi; Huang, Haojie; Huang, Wenlin; Chen, Shuai.

In: Nature Communications, Vol. 9, No. 1, 4381, 01.12.2018.

Research output: Contribution to journalArticle

Sheng, C, Yao, C, Wang, Z, Chen, H, Zhao, Y, Xu, D, Huang, H, Huang, W & Chen, S 2018, 'Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing', Nature Communications, vol. 9, no. 1, 4381. https://doi.org/10.1038/s41467-018-06756-3
Sheng, Chunjie ; Yao, Chen ; Wang, Ziyang ; Chen, Hongyuan ; Zhao, Yu ; Xu, Dazhi ; Huang, Haojie ; Huang, Wenlin ; Chen, Shuai. / Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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