Cyanide-induced parkinsonism: A clinicopathologic report

Ryan J. Uitti; A. H. Rajput; E. M. Ashenhurst; B. Rozdilsky

doi:10.1212/wnl.35.6.921

Cyanide-induced parkinsonism: A clinicopathologic report

Ryan J. Uitti, A. H. Rajput, E. M. Ashenhurst, B. Rozdilsky

Neurology

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110 Scopus citations

Abstract

An 18-year-old man ingested 975 to 1,300 mg of potassium cyanide in a suicide attempt. He was treated and survived the poisoning episode, but then had severe parkinsonian syndrome, characterized primarily by akinesia and rigidity. He died 19 months after the drug overdose. At autopsy, major destructive changes were found in the globus pal- lidus and putamen, whereas the melanin-containing zone of substantia nigra was intact. This is the first clinicopathologic report of parkinsonism as a result of cyanide poisoning.

Original language	English (US)
Pages (from-to)	921-925
Number of pages	5
Journal	Neurology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1212/wnl.35.6.921
State	Published - Jun 1985

ASJC Scopus subject areas

Clinical Neurology

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abstract = "An 18-year-old man ingested 975 to 1,300 mg of potassium cyanide in a suicide attempt. He was treated and survived the poisoning episode, but then had severe parkinsonian syndrome, characterized primarily by akinesia and rigidity. He died 19 months after the drug overdose. At autopsy, major destructive changes were found in the globus pal- lidus and putamen, whereas the melanin-containing zone of substantia nigra was intact. This is the first clinicopathologic report of parkinsonism as a result of cyanide poisoning.",

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AU - Rajput, A. H.

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AU - Rozdilsky, B.

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AB - An 18-year-old man ingested 975 to 1,300 mg of potassium cyanide in a suicide attempt. He was treated and survived the poisoning episode, but then had severe parkinsonian syndrome, characterized primarily by akinesia and rigidity. He died 19 months after the drug overdose. At autopsy, major destructive changes were found in the globus pal- lidus and putamen, whereas the melanin-containing zone of substantia nigra was intact. This is the first clinicopathologic report of parkinsonism as a result of cyanide poisoning.

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Cyanide-induced parkinsonism: A clinicopathologic report

Abstract

ASJC Scopus subject areas

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