Cutting the brakes and flooring the gas: How TMEPAI turns TGF-β into a tumor promoter

Magdalena A. Cichon, Derek C Radisky

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In normal or nonmalignant cells, TGF-β inhibits cellular proliferation through activation of the SMAD-dependent canonical signaling pathway. Recent findings demonstrate that the protein TMEPAI1 can block the cytostatic effects of the canonical TGF-β signaling pathway, while activating cellular proliferation through the noncanonical, SMAD-independent TGF-β signaling pathway. As TMEPAI1 shows increased expression in the poor prognosis basal and HER2 intrinsic subtypes of breast cancer, these findings point to a new avenue of targeted therapy with considerable therapeutic potential.

Original languageEnglish (US)
Pages (from-to)303-305
Number of pages3
JournalGenes and Cancer
Volume5
Issue number9-10
StatePublished - 2014

Keywords

  • Breast cancer
  • TGF beta
  • TMEPAI

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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