Custom designed acoustic pulses

Don C. Lamb, Jerri Tribble, Apostolos G. Doukas, Thomas J Flotte, Robert H. Ossoff, Lou Reinisch

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have used a tunable, infrared, free-electron laser with a Pockels cell controlled pulse duration to generate photoacoustic pulses with separate variable rise times (from 15 to 100 ns), durations (100-400 ns), and amplitudes (0.005-0.1 MPa). The tunability of the free-electron laser across water absorption bands allows the rise time of the thermal-elastically generated acoustical pulsed to be varied, while a Pockels cell controls the duration and cross polarizers control the pressure amplitude. The mechanical effects of pressure transients on biological tissue can have dramatic consequences. In addition to cell necrosis, carefully controlled pressure transients can also be used for therapeutic applications, such as drug delivery and gene therapy. This technique permits systemic probing of how biological tissue is affected by stress transients.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalJournal of Biomedical Optics
Volume4
Issue number2
DOIs
StatePublished - Apr 1999
Externally publishedYes

Fingerprint

Acoustics
Laser pulses
Free electron lasers
transient pressures
Pressure
acoustics
Lasers
pulses
free electron lasers
Electrons
Tissue
Gene therapy
Photoacoustic effect
cells
Water absorption
gene therapy
Drug delivery
Genetic Therapy
necrosis
Absorption spectra

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry
  • Atomic and Molecular Physics, and Optics

Cite this

Lamb, D. C., Tribble, J., Doukas, A. G., Flotte, T. J., Ossoff, R. H., & Reinisch, L. (1999). Custom designed acoustic pulses. Journal of Biomedical Optics, 4(2), 217-223. https://doi.org/10.1117/1.429912

Custom designed acoustic pulses. / Lamb, Don C.; Tribble, Jerri; Doukas, Apostolos G.; Flotte, Thomas J; Ossoff, Robert H.; Reinisch, Lou.

In: Journal of Biomedical Optics, Vol. 4, No. 2, 04.1999, p. 217-223.

Research output: Contribution to journalArticle

Lamb, DC, Tribble, J, Doukas, AG, Flotte, TJ, Ossoff, RH & Reinisch, L 1999, 'Custom designed acoustic pulses', Journal of Biomedical Optics, vol. 4, no. 2, pp. 217-223. https://doi.org/10.1117/1.429912
Lamb DC, Tribble J, Doukas AG, Flotte TJ, Ossoff RH, Reinisch L. Custom designed acoustic pulses. Journal of Biomedical Optics. 1999 Apr;4(2):217-223. https://doi.org/10.1117/1.429912
Lamb, Don C. ; Tribble, Jerri ; Doukas, Apostolos G. ; Flotte, Thomas J ; Ossoff, Robert H. ; Reinisch, Lou. / Custom designed acoustic pulses. In: Journal of Biomedical Optics. 1999 ; Vol. 4, No. 2. pp. 217-223.
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