Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma

R. Egensperger; B. Scheithauer; E. Horvath; K. Kovacs; C. Giannini; W. Young; R. Lloyd; J. Atkinson; T. Nippoldt

doi:10.1007/s004010100376

Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma

R. Egensperger, B. Scheithauer, E. Horvath, K. Kovacs, C. Giannini, W. Young, R. Lloyd, J. Atkinson, T. Nippoldt

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A 67-year-old woman presented with clinical features of hypercortisolism in association with an invasive pituitary macroadenoma. Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease was documented, and the resected tumor was chromophobic, weakly positive with periodic-Schiff reagent, and showed immunostaining for ACTH and β-endorphin in a minority of adenoma cells. Both luteinizing hormone and α-sub-unit staining were also observed, but no follicle-stimulating hormone reactivity was seen. Ultrastructurally, the tumor showed typical features of a gonadotroph adenoma of female type. Immunoelectron microscopy showed that ACTH was not produced in corticotrophs, but in cells with the characteristic features of gonadotrophs. This represents the second report of a plurihormonal gonadotroph adenoma producing sufficient ACTH to result in pituitary-dependent Cushing's disease.

Original language	English (US)
Pages (from-to)	398-403
Number of pages	6
Journal	Acta neuropathologica
Volume	102
Issue number	4
DOIs	https://doi.org/10.1007/s004010100376
State	Published - 2001

Keywords

Cushing's disease
Gonadotropins
Pituitary adenoma
Plurihormonality
Ultrastructure

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1007/s004010100376

Cite this

@article{9d324376e42d4ac3bc7c37a44fae555b,

title = "Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma",

abstract = "A 67-year-old woman presented with clinical features of hypercortisolism in association with an invasive pituitary macroadenoma. Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease was documented, and the resected tumor was chromophobic, weakly positive with periodic-Schiff reagent, and showed immunostaining for ACTH and β-endorphin in a minority of adenoma cells. Both luteinizing hormone and α-sub-unit staining were also observed, but no follicle-stimulating hormone reactivity was seen. Ultrastructurally, the tumor showed typical features of a gonadotroph adenoma of female type. Immunoelectron microscopy showed that ACTH was not produced in corticotrophs, but in cells with the characteristic features of gonadotrophs. This represents the second report of a plurihormonal gonadotroph adenoma producing sufficient ACTH to result in pituitary-dependent Cushing's disease.",

keywords = "Cushing's disease, Gonadotropins, Pituitary adenoma, Plurihormonality, Ultrastructure",

author = "R. Egensperger and B. Scheithauer and E. Horvath and K. Kovacs and C. Giannini and W. Young and R. Lloyd and J. Atkinson and T. Nippoldt",

note = "Funding Information: Acknowledgements The authors wish to thank Mr. and Mrs. S. Jarislowski, the Lloyd Carr-Harris Foundation, and Mr. and Mrs. James Wooters for their financial support, Ms. Sandy Cohen, Mr. Fabio Rotondo, and Mrs. Arlene Stewart for their valuable contribution to the morphologic studies, and Mrs. Julienne Montgomery for excellent secretarial support. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1007/s004010100376",

language = "English (US)",

volume = "102",

pages = "398--403",

journal = "Acta neuropathologica",

issn = "0001-6322",

publisher = "Springer Verlag",

number = "4",

}

TY - JOUR

T1 - Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma

AU - Egensperger, R.

AU - Scheithauer, B.

AU - Horvath, E.

AU - Kovacs, K.

AU - Giannini, C.

AU - Young, W.

AU - Lloyd, R.

AU - Atkinson, J.

AU - Nippoldt, T.

N1 - Funding Information: Acknowledgements The authors wish to thank Mr. and Mrs. S. Jarislowski, the Lloyd Carr-Harris Foundation, and Mr. and Mrs. James Wooters for their financial support, Ms. Sandy Cohen, Mr. Fabio Rotondo, and Mrs. Arlene Stewart for their valuable contribution to the morphologic studies, and Mrs. Julienne Montgomery for excellent secretarial support. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - A 67-year-old woman presented with clinical features of hypercortisolism in association with an invasive pituitary macroadenoma. Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease was documented, and the resected tumor was chromophobic, weakly positive with periodic-Schiff reagent, and showed immunostaining for ACTH and β-endorphin in a minority of adenoma cells. Both luteinizing hormone and α-sub-unit staining were also observed, but no follicle-stimulating hormone reactivity was seen. Ultrastructurally, the tumor showed typical features of a gonadotroph adenoma of female type. Immunoelectron microscopy showed that ACTH was not produced in corticotrophs, but in cells with the characteristic features of gonadotrophs. This represents the second report of a plurihormonal gonadotroph adenoma producing sufficient ACTH to result in pituitary-dependent Cushing's disease.

AB - A 67-year-old woman presented with clinical features of hypercortisolism in association with an invasive pituitary macroadenoma. Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease was documented, and the resected tumor was chromophobic, weakly positive with periodic-Schiff reagent, and showed immunostaining for ACTH and β-endorphin in a minority of adenoma cells. Both luteinizing hormone and α-sub-unit staining were also observed, but no follicle-stimulating hormone reactivity was seen. Ultrastructurally, the tumor showed typical features of a gonadotroph adenoma of female type. Immunoelectron microscopy showed that ACTH was not produced in corticotrophs, but in cells with the characteristic features of gonadotrophs. This represents the second report of a plurihormonal gonadotroph adenoma producing sufficient ACTH to result in pituitary-dependent Cushing's disease.

KW - Cushing's disease

KW - Gonadotropins

KW - Pituitary adenoma

KW - Plurihormonality

KW - Ultrastructure

UR - http://www.scopus.com/inward/record.url?scp=0034835943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034835943&partnerID=8YFLogxK

U2 - 10.1007/s004010100376

DO - 10.1007/s004010100376

M3 - Article

C2 - 11603817

AN - SCOPUS:0034835943

SN - 0001-6322

VL - 102

SP - 398

EP - 403

JO - Acta neuropathologica

JF - Acta neuropathologica

IS - 4

ER -

Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this