Cushing's disease due to plurihormonal adrenocorticotropic hormone and gonadotropin-producing pituitary adenoma

R. Egensperger, B. Scheithauer, E. Horvath, K. Kovacs, C. Giannini, W. Young, R. Lloyd, J. Atkinson, T. Nippoldt

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A 67-year-old woman presented with clinical features of hypercortisolism in association with an invasive pituitary macroadenoma. Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease was documented, and the resected tumor was chromophobic, weakly positive with periodic-Schiff reagent, and showed immunostaining for ACTH and β-endorphin in a minority of adenoma cells. Both luteinizing hormone and α-sub-unit staining were also observed, but no follicle-stimulating hormone reactivity was seen. Ultrastructurally, the tumor showed typical features of a gonadotroph adenoma of female type. Immunoelectron microscopy showed that ACTH was not produced in corticotrophs, but in cells with the characteristic features of gonadotrophs. This represents the second report of a plurihormonal gonadotroph adenoma producing sufficient ACTH to result in pituitary-dependent Cushing's disease.

Original languageEnglish (US)
Pages (from-to)398-403
Number of pages6
JournalActa neuropathologica
Volume102
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Cushing's disease
  • Gonadotropins
  • Pituitary adenoma
  • Plurihormonality
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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