Current theories on the causes of inflammatory bowel disease

K. A. Papadakis, S. R. Targan

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

The understanding of the pathogenesis of Crohn's disease and ulcerative colitis has greatly expanded over the last decade. The combination of abnormalities in the immune system, the contribution of nonimmune cells in the intestinal mucosa, a variety of genetic risk determinants, and random environmental factors may all be necessary to induce what clinically presents as inflammatory bowel disease. It is likely that several agents can initiate an immune response that in the intestinal microenvironment and the genetic background of the patient finally leads to pathology.

Original languageEnglish (US)
Pages (from-to)283-296
Number of pages14
JournalGastroenterology Clinics of North America
Volume28
Issue number2
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Current theories on the causes of inflammatory bowel disease'. Together they form a unique fingerprint.

Cite this