Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma

Jean Sébastien Claveau; Francis K. Buadi; Shaji Kumar

doi:10.1007/s40487-022-00195-3

Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma

Jean Sébastien Claveau, Francis K. Buadi, Shaji Kumar

Hematology

Research output: Contribution to journal › Review article › peer-review

Abstract

Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients. However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.

Original language	English (US)
Pages (from-to)	105-122
Number of pages	18
Journal	Oncology and Therapy
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/s40487-022-00195-3
State	Published - Jun 2022

Keywords

Allogeneic transplantation
CAR-T cell therapy
Chronic graft-versus-host disease
Multiple myeloma

ASJC Scopus subject areas

Oncology

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10.1007/s40487-022-00195-3

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title = "Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma",

abstract = "Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients. However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.",

keywords = "Allogeneic transplantation, CAR-T cell therapy, Chronic graft-versus-host disease, Multiple myeloma",

author = "Claveau, {Jean S{\'e}bastien} and Buadi, {Francis K.} and Shaji Kumar",

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AU - Claveau, Jean Sébastien

AU - Buadi, Francis K.

AU - Kumar, Shaji

PY - 2022/6

Y1 - 2022/6

N2 - Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients. However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.

AB - Major progress in the treatment of multiple myeloma has been made in the last several years. However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients. However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.

KW - Allogeneic transplantation

KW - CAR-T cell therapy

KW - Chronic graft-versus-host disease

KW - Multiple myeloma

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ER -

Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma

Abstract

Keywords

ASJC Scopus subject areas

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