TY - JOUR
T1 - Current Medical Treatments of Dyspepsia and Irritable Bowel Syndrome
AU - Camilleri, Michael
AU - Tack, Jan F.
PY - 2010/9
Y1 - 2010/9
N2 - Dyspepsia is a highly prevalent condition characterized by symptoms originating in the gastroduodenal region without underlying organic disorder. Treatment modalities include acid-suppressive drugs, gastroprokinetic drugs, Helicobacter pylori eradication therapy, tricyclic antidepressants, and psychological therapies. Irritable bowel syndrome is a multifactorial, lower functional gastrointestinal disorder involving disturbances of the brain-gut axis. The pathophysiology provides the basis for pharmacotherapy: abnormal gastrointestinal motor functions, visceral hypersensitivity, psychosocial factors, intraluminal changes, and mucosal immune activation. Medications targeting chronic constipation or diarrhea may also relieve irritable bowel syndrome. Novel approaches to treatment require approval, and promising agents are guanylate cyclase cagonists, atypical benzodiazepines, antibiotics, immune modulators, and probiotics.
AB - Dyspepsia is a highly prevalent condition characterized by symptoms originating in the gastroduodenal region without underlying organic disorder. Treatment modalities include acid-suppressive drugs, gastroprokinetic drugs, Helicobacter pylori eradication therapy, tricyclic antidepressants, and psychological therapies. Irritable bowel syndrome is a multifactorial, lower functional gastrointestinal disorder involving disturbances of the brain-gut axis. The pathophysiology provides the basis for pharmacotherapy: abnormal gastrointestinal motor functions, visceral hypersensitivity, psychosocial factors, intraluminal changes, and mucosal immune activation. Medications targeting chronic constipation or diarrhea may also relieve irritable bowel syndrome. Novel approaches to treatment require approval, and promising agents are guanylate cyclase cagonists, atypical benzodiazepines, antibiotics, immune modulators, and probiotics.
KW - Clinical trials
KW - Opioids
KW - Pharmacodynamics
KW - Pharmacology
KW - Serotonergics
UR - http://www.scopus.com/inward/record.url?scp=77957923650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957923650&partnerID=8YFLogxK
U2 - 10.1016/j.gtc.2010.08.005
DO - 10.1016/j.gtc.2010.08.005
M3 - Review article
C2 - 20951913
AN - SCOPUS:77957923650
SN - 0889-8553
VL - 39
SP - 481
EP - 493
JO - Gastroenterology Clinics of North America
JF - Gastroenterology Clinics of North America
IS - 3
ER -