Current limits and future challenges in the management of renal dysfunction in patients with cirrhosis: Report from the International Club of Ascites

Paolo Angeli, Arun Sanyal, Soren Moller, Carlo Alessandria, Adrian Gadano, Ray Kim, Shiv K. Sarin, Mauro Bernardi

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Advanced cirrhosis is often complicated by a multi organ failure syndrome which involves many different organs besides the liver. The high morbidity and mortality secondary to this clinical setting is often related to renal dysfunction, either alone or, more frequently, in combination with other organ dysfunction. A clear defintion of renal dysfunction, an accurate differential diagnostic process of its different phenotypes as well as of full understanding of its pathophysiological mechanisms are crucial to the development of strategies for the management of this complication. This article is based either on the more recent knowledge on renal dysfunction in advanced cirrhosis or current opinions among the members of the International Club of Ascites (ICA) on the management of this complication, obtained through a survey and discussed during the EASL-ICA Joint Meeting in Berlin in March 2011. It reviews critically our current knowledge and it outlines future perspectives, on the management of renal dysfunction in patients with cirrhosis.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalLiver International
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Albumin
  • Hepatorenal syndrome
  • Renal failure
  • Serum creatinine
  • Terlipressin

ASJC Scopus subject areas

  • Hepatology

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