Current applications of molecular cytogenetic technologies

H. F L Mark, Robert Brian Jenkins, Wayne A. Miller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This review discusses select current applications of fluorescent in situ hybridization (FISH) which may be of utility for the average clinical cytogenetic laboratory. Owing to the large number of men and women affected, the applications chosen to illustrate the use of FISH technology in cancer focus on two diseases: breast cancer and prostate cancer. The applicability of FISH to detect common aneuploidies, such as trisomy 21, trisomy 18, trisomy 13 and the sex chromosome aneuploidies in prenatal diagnosis, is discussed, as well as FISH for the detection of microdeletions and microduplications. Quality assurance/quality control issues and standards and guidelines relating to laboratory practices in molecular cytogenetic testing are reviewed.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalAnnals of Clinical and Laboratory Science
Volume27
Issue number1
StatePublished - 1997

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Fluorescence In Situ Hybridization
Cytogenetics
Clinical laboratories
Technology
Aneuploidy
Quality assurance
Quality control
Prostatic Neoplasms
Sex Chromosomes
Testing
Down Syndrome
Prenatal Diagnosis
Quality Control
Guidelines
Breast Neoplasms
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry

Cite this

Current applications of molecular cytogenetic technologies. / Mark, H. F L; Jenkins, Robert Brian; Miller, Wayne A.

In: Annals of Clinical and Laboratory Science, Vol. 27, No. 1, 1997, p. 47-56.

Research output: Contribution to journalArticle

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