Current and emerging targeted therapies for metastatic breast cancer

Edith A. Perez, Jean Philippe Spano

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

The success of endocrine therapies for hormone receptor-positive breast cancer and trastuzumab and lapatinib for targeting human epidermal growth factor receptor 2 (HER2)-positive tumors has paved the way for the clinical development of several other metastatic breast cancer (MBC)-targeted therapies. Although the benefit of the anti-VEGF (vascular endothelial growth factor) monoclonal antibody bevacizumab in the MBC setting has become a topic of debate, clinical trial results are accumulating, and phase 3 evaluations are ongoing for newer HER2-targeted agents (pertuzumab and trastuzumab-maytansine immunoconjugate) and VEGF-targeted agents (aflibercept), as well as dual, epidermal growth factor receptor/HER2-targeted agents (afatinib [BIBW 2992] and neratinib), multitargeted tyrosine kinase inhibitors (sunitinib and pazopanib), and mammalian target of rapamycin (everolimus) and poly (ADP-ribose) polymerase 1 inhibitors (iniparib, olaparib). These agents as well as other novel classes of anticancer agents are being tested in clinical trials with the potential of addressing unmet therapeutic needs in the MBC patient population.

Original languageEnglish (US)
Pages (from-to)3014-3025
Number of pages12
JournalCancer
Volume118
Issue number12
DOIs
StatePublished - Jun 15 2012

Keywords

  • Epidermal growth factor receptor
  • Human epidermal growth factor receptor 2
  • Metastatic breast cancer
  • Multitargeted tyrosine kinase inhibitors
  • Targeted therapies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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