CT depiction of experimental liver tumors: Contrast enhancement with hepatocyte-selective iodinated triglyceride versus conventional techniques

Fred T. Lee, Susan G. Chosy, Sauen G. Naidu, Stanley Goldfarb, Jamey P. Weichert, Douglas A. Bakan, Janet E. Kuhlman, Robert H. Tambeaux, Ian A. Sproat

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

PURPOSE: To compare findings at computed tomography (CT) enhanced with a hepatocyte-selective contrast agent (iodinated triglyceride) and/or iohexol and at CT during arterial portography (CTAP). MATERIALS AND METHODS: Rabbit livers were directly inoculated with VX2 carcinoma. Results were compared for five helical CT examinations: unenhanced CT, iohexol-enhanced CT (600 mg iodine per kilogram of body weight [mg I/kg]), CTAP (with iohexol [600 mg I/kg]), triglyceride-enhanced CT (126 mg I/kg), and dual-contrast-enhanced CT (triglyceride plus iohexol [425 mg I/kg]). Attenuation of normal liver and tumor were compared with analysis of variance techniques and blinded reader evaluations. RESULTS: Normal liver attenuation was greatest at CTAP (127.3 HU ± 5.3 [mean ± standard error of the mean]), followed by dual-contrast- enhanced CT (112.4 HU ± 1.2), iohexol-enhanced CT (97.9 HU ± 2.2), triglyceride-enhanced CT (82.3 HU ± 1.1), and unenhanced CT (54.9 HU ± 1.8). Liver-to-lesion attenuation difference at triglyceride-enhanced CT was significantly greater than at iohexol-enhanced CT (P < .05), and attenuation differences at dual-contrast-enhanced CT were comparable to those at CTAP. Tumors did not enhance at triglyceride-enhanced CT, which increased conspicuity. Sensitivity values for lesion detection at dual-contrast- enhanced CT were greater than those at iohexol-enhanced CT or at CTAP (P < .05). CONCLUSION: At CT enhanced with triglyceride (especially when combined with iohexol), sensitivity values and liver-to-lesion attenuation differences were greater with lower iodine doses than with iohexol or at CTAP.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalRadiology
Volume203
Issue number2
DOIs
StatePublished - May 1997

Keywords

  • Computed tomography (CT), comparative studies
  • Computed tomography (CT), contrast media
  • Contrast media, experimental studies
  • Iohexol
  • Liver neoplasms, CT
  • Liver, CT
  • Portography
  • Triglycerides

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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