CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis

Osman Kursat Arikan, Can Koc, Tuba Kendi, Nuray Bayar Muluk, Aydanur Ekici

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Conclusion. Fluticasone propionate (FP) aqueous nasal spray was objectively found to be effective and safe for the treatment of lower turbinate enlargement in patients with vasomotor rhinitis. Objective. To assess the efficacy of FP aqueous nasal spray treatment in lower turbinate hypertrophy due to vasomotor rhinitis using CT. Material and methods. Of 35 patients with hypertrophic lower turbinates due to vasomotor rhinitis, 20 were treated twice daily with FP aqueous nasal spray (200 μg/day) for 3 months continuously and 15 were treated with placebo vehicle as a control group. The local effect of the nasal spray was studied using CT and visual analog scales. Results. Treatment with FP provided significantly greater relief from the symptom of nasal obstruction compared with placebo over the entire 3-month treatment period (p < 0.001). When the change from baseline was compared between the two groups, FP produced statistically significant reductions in the mucosal area of the lower turbinates and in the thickness of the nasal mucosa after 3 months (p < 0.05).

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalActa Oto-Laryngologica
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • CT
  • Fluticasone propionate
  • Lower turbinate hypertrophy
  • Vasomotor rhinitis

ASJC Scopus subject areas

  • Otorhinolaryngology

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