Crosstalk of DNA glycosylases with pathways other than base excision repair

Irina V. Kovtun; Cynthia T. McMurray

doi:10.1016/j.dnarep.2006.10.015

Crosstalk of DNA glycosylases with pathways other than base excision repair

Irina V. Kovtun, Cynthia T. McMurray

Pharmacology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

While a role for DNA glycosylase activity in base excision repair (BER) is well understood, there is mounting evidence to implicate cooperation of DNA glycosylases with components of repair pathways other than BER. The mechanisms by which DNA glycosylases interact with non-BER pathways are, in many cases, poorly understood. However, accumulating evidence indicates that crosstalk is common and may be as important in signaling repair as the canonical pathways themselves.

Original language	English (US)
Pages (from-to)	517-529
Number of pages	13
Journal	DNA Repair
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.dnarep.2006.10.015
State	Published - Apr 1 2007

Keywords

Base excision repair
Crosstalk
Glycosylase
Mismatch repair
Transcription

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2006.10.015

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title = "Crosstalk of DNA glycosylases with pathways other than base excision repair",

abstract = "While a role for DNA glycosylase activity in base excision repair (BER) is well understood, there is mounting evidence to implicate cooperation of DNA glycosylases with components of repair pathways other than BER. The mechanisms by which DNA glycosylases interact with non-BER pathways are, in many cases, poorly understood. However, accumulating evidence indicates that crosstalk is common and may be as important in signaling repair as the canonical pathways themselves.",

keywords = "Base excision repair, Crosstalk, Glycosylase, Mismatch repair, Transcription",

author = "Kovtun, {Irina V.} and McMurray, {Cynthia T.}",

note = "Funding Information: This work was supported by the Mayo Foundation, the National Institutes of Health grants NS40738 (C.T.M.), and GM 066359 (C.T.M.).",

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AU - Kovtun, Irina V.

AU - McMurray, Cynthia T.

N1 - Funding Information: This work was supported by the Mayo Foundation, the National Institutes of Health grants NS40738 (C.T.M.), and GM 066359 (C.T.M.).

PY - 2007/4/1

Y1 - 2007/4/1

N2 - While a role for DNA glycosylase activity in base excision repair (BER) is well understood, there is mounting evidence to implicate cooperation of DNA glycosylases with components of repair pathways other than BER. The mechanisms by which DNA glycosylases interact with non-BER pathways are, in many cases, poorly understood. However, accumulating evidence indicates that crosstalk is common and may be as important in signaling repair as the canonical pathways themselves.

AB - While a role for DNA glycosylase activity in base excision repair (BER) is well understood, there is mounting evidence to implicate cooperation of DNA glycosylases with components of repair pathways other than BER. The mechanisms by which DNA glycosylases interact with non-BER pathways are, in many cases, poorly understood. However, accumulating evidence indicates that crosstalk is common and may be as important in signaling repair as the canonical pathways themselves.

KW - Base excision repair

KW - Crosstalk

KW - Glycosylase

KW - Mismatch repair

KW - Transcription

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ER -

Crosstalk of DNA glycosylases with pathways other than base excision repair

Abstract

Keywords

ASJC Scopus subject areas

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