Crosstalk of DNA glycosylases with pathways other than base excision repair

Irina V. Kovtun, Cynthia T. McMurray

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

While a role for DNA glycosylase activity in base excision repair (BER) is well understood, there is mounting evidence to implicate cooperation of DNA glycosylases with components of repair pathways other than BER. The mechanisms by which DNA glycosylases interact with non-BER pathways are, in many cases, poorly understood. However, accumulating evidence indicates that crosstalk is common and may be as important in signaling repair as the canonical pathways themselves.

Original languageEnglish (US)
Pages (from-to)517-529
Number of pages13
JournalDNA Repair
Volume6
Issue number4
DOIs
StatePublished - Apr 1 2007

Keywords

  • Base excision repair
  • Crosstalk
  • Glycosylase
  • Mismatch repair
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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