Crosslinking characteristics of an injectable poly(propylene fumarate)/β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement

S. J. Peter, P. Kim, A. W. Yasko, Michael J Yaszemski, A. G. Mikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We investigated the crosslinking characteristics of an injectable composite paste of poly(propylene fumarate) (PPF), N-vinyl pyrrolidinone (N-VP), benzoyl peroxide (BP), sodium chloride (NaCl), and β-tricalcium phosphate (β-TCP). We examined the effects of PPF molecular weight, N-VP/PPF ratio, BP/PPF ratio, and NaCl weight percent on the crosslinking temperature, heat release upon crosslinking, gel point, and the composite compressive strength and modulus. The maximum crosslinking temperature did not vary widely between formulations, with the absolute values falling between 38 and 48 °C, and was much lower than that of 94 °C for poly(methyl methacrylate) bone cement controls tested under the same conditions. The total heat released upon crosslinking was decreased by an increase in PPF molecular weight and a decrease in N-VP/PPF ratio. The gel point was effected strongly by the PPF molecular weight, with a decrease in PPF molecular weight leading to a more rapid gel point. An increase in initiator concentration had the same effect to a lesser degree. The time frame for curing was varied from 1121 minutes, allowing the composite to be tailored to specific applications. The compressive strength and compressive modulus values increased with decreasing N-VP/PPF, increasing NaCl content, and increasing BP/PPF ratio. For all formulations, the compressive strength values fell between 1 and 12 MPa, and the compressive modulus values fell between 23 and 265 MPa. These data suggest that injectable PPF/β-TCP pastes can be prepared with handling characteristics appropriate for clinical orthopaedic applications and that the mechanical properties of the cured composites are suitable for trabecular bone replacement.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium - Proceedings
PublisherMRS
Pages87-92
Number of pages6
Volume530
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 MRS Symposium - San Francisco, CA, USA
Duration: Apr 13 1998Apr 14 1998

Other

OtherProceedings of the 1998 MRS Symposium
CitySan Francisco, CA, USA
Period4/13/984/14/98

Fingerprint

Bone cement
Bone Cements
Fumarates
Adhesive pastes
Ointments
Crosslinking
Propylene
Polypropylenes
Phosphates
Mechanical properties
Composite materials
Pyrrolidinones
Benzoyl Peroxide
Benzoyl peroxide
Molecular weight
Compressive strength
Gels
tricalcium phosphate
poly(propylene fumarate)
propylene

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Peter, S. J., Kim, P., Yasko, A. W., Yaszemski, M. J., & Mikos, A. G. (1998). Crosslinking characteristics of an injectable poly(propylene fumarate)/β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. In Materials Research Society Symposium - Proceedings (Vol. 530, pp. 87-92). MRS.

Crosslinking characteristics of an injectable poly(propylene fumarate)/β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. / Peter, S. J.; Kim, P.; Yasko, A. W.; Yaszemski, Michael J; Mikos, A. G.

Materials Research Society Symposium - Proceedings. Vol. 530 MRS, 1998. p. 87-92.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Peter, SJ, Kim, P, Yasko, AW, Yaszemski, MJ & Mikos, AG 1998, Crosslinking characteristics of an injectable poly(propylene fumarate)/β-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement. in Materials Research Society Symposium - Proceedings. vol. 530, MRS, pp. 87-92, Proceedings of the 1998 MRS Symposium, San Francisco, CA, USA, 4/13/98.
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