@inbook{4bf77711d4d64385a5c00230d6e1cfeb,
title = "Critical signal transduction pathways in CLL",
abstract = "Receptor tyrosine kinases (RTKs) are cell-surface transmembrane receptors that contain regulated kinase activity within their cytoplasmic domain and play a critical role in signal transduction in both normal and malignant cells. Besides B cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL), multiple RTKs have been reported to be constitutively active in CLL B cells, resulting in enhanced survival and resistance to apoptosis of the leukemic cells induced by chemotherapeutic agents. In addition to increased plasma levels of various types of cytokines/growth factors in CLL, we and others have detected that CLL B cells spontaneously produce multiple cytokines in vitro which may constitute an autocrine loop of RTK activation on the leukemic B cells. Moreover, aberrant expression and activation of non-RTKs, for example, Src/Syk kinases, induce resistance of the leukemic B cells to therapy. Based on current available knowledge, we detailed the impact of aberrant activities of various RTKs/non-RTKs on CLL B cell survival and the potential of using these signaling components as future therapeutic targets in CLL therapy.",
keywords = "Apoptosis, CLL, Kinase inhibitor, Non-RTK, RTK, Signal transduction, Therapy",
author = "Ghosh, {Asish K.} and Kay, {Neil E.}",
year = "2013",
doi = "10.1007/978-1-4614-8051-8-10",
language = "English (US)",
isbn = "9781461480501",
volume = "792",
series = "Advances in Experimental Medicine and Biology",
pages = "215--239",
booktitle = "Advances in Experimental Medicine and Biology",
}