Abstract
Advances in our understanding of T cell costimulatory molecules have provided a vast array of novel approaches to tumor immunotherapy. In the past year, combinatorial immunotherapy based on earlier studies of CTLA-4 blockade, the identification of novel B7-family members, the modulation of CD40 to reverse tolerance to tumor-associated antigens and the use of OX40 to enhance antitumor responses of CD4+ T cells have all contributed to the development of more-powerful immunomodulatory cancer therapies. (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 589-596 |
Number of pages | 8 |
Journal | Current Opinion in Immunology |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - 2000 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology