Cosmology inspired design of biomimetic tissue engineering templates with Gaussian random fields

Srinivasan Rajagopalan, Richard A. Robb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Tissue engineering integrates the principles of engineering and life sciences toward the design, construction, modification and growth of biological substitutes that restore, maintain, or improve tissue function. The structural integrity and ultimate functionality of such tissue analogs is defined by scaffolds- porous, three-dimensional "trellis-like" structures that, on implantation, provide a viable environment to regenerate damaged tissues. The orthogonal scaffold fabrication methods currently employed can be broadly classified into two categories: (a) conventional, irreproducible, stochastic techniques producing reasonably biomorphic scaffold architecture, and (b) rapidly emerging, repeatable, computer-controlled techniques producing straight edged "contra naturam" scaffold architecture. In this paper, we present the results of the first attempt in an image-based scaffold modeling and optimization strategy that synergistically exploits the orthogonal fabrication techniques to create repeatable, biomorphic scaffolds with optimal scaffold morphology. Motivated by the use of Gaussian random fields (GRF) to model cosmological structure formation, we use appropriately ordered and clipped stacks of GRF to model the three-dimensional pore-solid scaffold labyrinths. Image-based metrology, fabrication and mechanical characterization of these scaffolds reveal the possibility of enabling the previously elusive deployment of promising benchside tissue analogs to the clinical bedside.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages544-552
Number of pages9
Volume4191 LNCS - II
StatePublished - 2006
Event9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - Copenhagen, Denmark
Duration: Oct 1 2006Oct 6 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4191 LNCS - II
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
CountryDenmark
CityCopenhagen
Period10/1/0610/6/06

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Computer Science(all)
  • Theoretical Computer Science

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  • Cite this

    Rajagopalan, S., & Robb, R. A. (2006). Cosmology inspired design of biomimetic tissue engineering templates with Gaussian random fields. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4191 LNCS - II, pp. 544-552). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4191 LNCS - II).