Corynebacterium prosthetic joint infection

Charles Cazanave, Kerryl E. Greenwood-Quaintance, Arlen D. Hanssen, Robin Patel

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Identification of Corynebacterium species may be challenging. Corynebacterium species are occasional causes of prosthetic joint infection (PJI), but few data are available on the subject. Based on the literature, C. amycolatum, C. aurimucosum, C. jeikeium, and C. striatum are the most common Corynebacterium species that cause PJI. We designed a rapid PCR assay to detect the most common human Corynebacterium species, with a specific focus on PJI. A polyphosphate kinase gene identified using whole-genome sequence was targeted. The assay differentiates the antibiotic-resistant species C. jeikeium and C. urealyticum from other species in a single assay. The assay was applied to a collection of human Corynebacterium isolates from multiple clinical sources, and clinically relevant species were detected. The assay was then tested on Corynebacterium isolates specifically associated with PJI; all were detected. We also describe the first case of C. simulans PJI.

Original languageEnglish (US)
Pages (from-to)1518-1523
Number of pages6
JournalJournal of clinical microbiology
Volume50
Issue number5
DOIs
StatePublished - May 2012

ASJC Scopus subject areas

  • Microbiology (medical)

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    Cazanave, C., Greenwood-Quaintance, K. E., Hanssen, A. D., & Patel, R. (2012). Corynebacterium prosthetic joint infection. Journal of clinical microbiology, 50(5), 1518-1523. https://doi.org/10.1128/JCM.06439-11