Cortical thickness and anxiety symptoms among cognitively normal elderly persons: The mayo clinic study of aging

Anna Pink, Scott A. Przybelski, Janina Krell-Roesch, Gorazd B. Stokin, Rosebud O Roberts, Michelle M Mielke, Kathleen A. Spangehl, David S Knopman, Clifford R Jr. Jack, Ronald Carl Petersen, Yonas Endale Geda

Research output: Contribution to journalArticle

4 Scopus citations


The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged $70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
StatePublished - 2017


ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Psychiatry and Mental health

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