@article{741d35bc6e0d44769a05b648ed9852f8,
title = "Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging",
abstract = "Introduction: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.",
keywords = "cluster analysis, cortical thickness, mild cognitive impairment, neuropsychology",
author = "Machulda, {Mary M.} and Lundt, {Emily S.} and Albertson, {Sabrina M.} and Spychalla, {Anthony J.} and Schwarz, {Christopher G.} and Mielke, {Michelle M.} and Jack, {Clifford R.} and Kremers, {Walter K.} and Prashanthi Vemuri and Knopman, {David S.} and Jones, {David T.} and Bondi, {Mark W.} and Petersen, {Ronald C.}",
note = "Funding Information: The authors wish to thank the participants and staff at the Mayo Clinic Study of Aging. This research was made possible by the National Institutes of HealthR01 AG49810, R37 AG011378, R01 AG041851, R01 AG056366, R01 NS097495, U01 AG06786, R01 AG034676, P50 AG016574, Alexander Family Professorship of Alzheimer's Disease Research, The Elsie and Marvin Dekelboum Family Foundation, The GHR Foundation, The Robert Wood Johnson Foundation, and by the Mayo Foundation for Education and Research. Funding Information: The authors wish to thank the participants and staff at the Mayo Clinic Study of Aging. This research was made possible by the National Institutes of HealthR01 AG49810, R37 AG011378, R01 AG041851, R01 AG056366, R01 NS097495, U01 AG06786, R01 AG034676, P50 AG016574, Alexander Family Professorship of Alzheimer's Disease Research, The Elsie and Marvin Dekelboum Family Foundation, The GHR Foundation, The Robert Wood Johnson Foundation, and by the Mayo Foundation for Education and Research. MMM: design and conceptualization of the study, data collection, analysis and interpretation of the data, drafting the manuscript, study funding, revising the manuscript. ESL: design and conceptualization of the study, analysis and interpretation of the data, drafting the manuscript, revising the manuscript. SMA: design and conceptualization of the study, analysis and interpretation of the data, drafting the manuscript, revising the manuscript. AJS: analysis of data, revising the manuscript. CS: analysis of data, drafting the manuscript, revising the manuscript. MMM: data collection, analysis and interpretation of the data, revising the manuscript. CRJ: data collection, analysis and interpretation of the data, drafting the manuscript, study funding, revising the manuscript. WKK: analysis and interpretation of the data, drafting the manuscript, study funding, revising the manuscript. PV: revising the manuscript. DSK: data collection, revising the manuscript. DTJ: revising the manuscript. MWB: design and conceptualization of the study, drafting the manuscript, study funding, revising the manuscript. RCP: data collection, analysis and interpretation of the data, drafting the manuscript, study funding, revising the manuscript. Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.",
year = "2020",
month = jul,
day = "1",
doi = "10.1002/alz.12108",
language = "English (US)",
volume = "16",
pages = "1013--1022",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "7",
}