Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Mary M. Machulda; Emily S. Lundt; Sabrina M. Albertson; Anthony J. Spychalla; Christopher G. Schwarz; Michelle M. Mielke; Clifford R. Jack; Walter K. Kremers; Prashanthi Vemuri; David S. Knopman; David T. Jones; Mark W. Bondi; Ronald C. Petersen

doi:10.1002/alz.12108

Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Mary M. Machulda, Emily S. Lundt, Sabrina M. Albertson, Anthony J. Spychalla, Christopher G. Schwarz, Michelle M. Mielke, Clifford R. Jack, Walter K. Kremers, Prashanthi Vemuri, David S. Knopman, David T. Jones, Mark W. Bondi, Ronald C. Petersen

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.

Original language	English (US)
Pages (from-to)	1013-1022
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	16
Issue number	7
DOIs	https://doi.org/10.1002/alz.12108
State	Published - Jul 1 2020

Keywords

cluster analysis
cortical thickness
mild cognitive impairment
neuropsychology

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1002/alz.12108

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Machulda, M. M., Lundt, E. S., Albertson, S. M., Spychalla, A. J., Schwarz, C. G., Mielke, M. M., Jack, C. R., Kremers, W. K., Vemuri, P., Knopman, D. S., Jones, D. T., Bondi, M. W., & Petersen, R. C. (2020). Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging. Alzheimer's and Dementia, 16(7), 1013-1022. https://doi.org/10.1002/alz.12108

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abstract = "Introduction: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.",

keywords = "cluster analysis, cortical thickness, mild cognitive impairment, neuropsychology",

author = "Machulda, {Mary M.} and Lundt, {Emily S.} and Albertson, {Sabrina M.} and Spychalla, {Anthony J.} and Schwarz, {Christopher G.} and Mielke, {Michelle M.} and Jack, {Clifford R.} and Kremers, {Walter K.} and Prashanthi Vemuri and Knopman, {David S.} and Jones, {David T.} and Bondi, {Mark W.} and Petersen, {Ronald C.}",

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AU - Jack, Clifford R.

AU - Kremers, Walter K.

AU - Vemuri, Prashanthi

AU - Knopman, David S.

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AU - Bondi, Mark W.

AU - Petersen, Ronald C.

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N2 - Introduction: We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods: We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results: The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion: We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.

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Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

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