Correlation of resting first-pass left ventricular ejection fraction and resting myocardial infarct size

Panithaya Chareonthaitawee, Timothy F. Christian, Todd D. Miller, David O. Hodge, Raymond J. Gibbons

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


This study determined the correlation between the extent of the resting perfusion defect by technetium-99m sestamibi tomographic imaging and the first-pass left ventricular (LV) ejection fraction (EF). A total of 1,955 patients underwent technetium-99m sestamibi tomographic imaging with measurement of first-pass resting LVEF. Twenty-five percent of patients had a prior history of myocardial infarction. First-pass LVEF was measured using a peripheral intravenous injection and a multicrystal gamma camera with standard software. Resting tomographic perfusion defect size (infarct size) was quantitated using previously published methods. Mean LVEF for the study group was 0.60 ± 0.11. Mean LV infarct size was 5 ± 11%. For the 1,265 patients (65% of the study group) with no measurable perfusion defect, the prevalence of a normal (≤0.50) LVEF was 96% (1,212 of 1,265 patients). For patients with a measurable defect (n = 690, 35%), the inverse linear correlation with LVEF was highly significant (r = -0.60, p <0.0001) but with wide confidence limits (SEE = 10 LVEF points), thereby limiting the predictive value in individual patients. Thus, in the absence of known cardiomyopathy, valvular heart disease, or left bundle branch block, patients without a quantifiable resting perfusion defect are highly likely to have a normal resting LVEF and may not require determination of LV function. For patients with resting perfusion defects, LVEF cannot be predicted with confidence and should therefore be measured.

Original languageEnglish (US)
Pages (from-to)1281-1285
Number of pages5
JournalAmerican Journal of Cardiology
Issue number11
StatePublished - Jun 1 1998

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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