Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Marat Fudim; Vanessa L. Blumer; Renato D. Lopes; Patrick Rossignol; Michael Feldschuh; Wayne L. Miller; Paul A. Sobotka

doi:10.1007/s12265-019-09910-4

Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Marat Fudim, Vanessa L. Blumer, Renato D. Lopes, Patrick Rossignol, Michael Feldschuh, Wayne L. Miller, Paul A. Sobotka

Cardiovascular Medicine

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from − 23 to + 28% for TBV, − 22 to + 36% for PV and − 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = − 0.03; PV and SBP, r = − 0.12; RBV and SBP, r = − 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

Original language	English (US)
Pages (from-to)	528-530
Number of pages	3
Journal	Journal of cardiovascular translational research
Volume	13
Issue number	4
DOIs	https://doi.org/10.1007/s12265-019-09910-4
State	Published - Aug 1 2020

Keywords

Blood volume analysis
Gender
Hypertension
Race

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmaceutical Science
Cardiology and Cardiovascular Medicine
Genetics(clinical)

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10.1007/s12265-019-09910-4

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abstract = "Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from − 23 to + 28% for TBV, − 22 to + 36% for PV and − 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = − 0.03; PV and SBP, r = − 0.12; RBV and SBP, r = − 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.",

keywords = "Blood volume analysis, Gender, Hypertension, Race",

author = "Marat Fudim and Blumer, {Vanessa L.} and Lopes, {Renato D.} and Patrick Rossignol and Michael Feldschuh and Miller, {Wayne L.} and Sobotka, {Paul A.}",

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T1 - Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

AU - Fudim, Marat

AU - Blumer, Vanessa L.

AU - Lopes, Renato D.

AU - Rossignol, Patrick

AU - Feldschuh, Michael

AU - Miller, Wayne L.

AU - Sobotka, Paul A.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from − 23 to + 28% for TBV, − 22 to + 36% for PV and − 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = − 0.03; PV and SBP, r = − 0.12; RBV and SBP, r = − 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

AB - Volume management is an essential component of anti-hypertensive therapy. Different volume phenotypes have been proposed. We sought to study the total blood volume (TBV), plasma volume (PV), and red blood cell volume (RBV) in hypertensive patients. We included patients followed in an outpatient cardiology clinic from 1998 to 2003. Blood volume (BV) parameters were measured using radioisotope iodine-131-labeled albumin dilution technique. Values were expressed as percentage (%) deviation from ideal volumes. A total of 95 patients were included. The intravascular volume distribution as percent deviation from normal volume ranged from − 23 to + 28% for TBV, − 22 to + 36% for PV and − 29 to + 37% for RBV. There was no significant correlation between systolic BP and any of the BV parameters (TBV and SBP, r = − 0.03; PV and SBP, r = − 0.12; RBV and SBP, r = − 0.08). Patients with hypertension have a wide variation in BV parameters. BV does not correlate with SBP.

KW - Blood volume analysis

KW - Gender

KW - Hypertension

KW - Race

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Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension

Abstract

Keywords

ASJC Scopus subject areas

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