Coronary microvascular functional reserve: Quantification of long-term changes with electron-beam CT - Preliminary results in a porcine model

S. Möhlenkamp, T. R. Behrenbeck, A. Lerman, L. O. Lerman, V. S. Pankratz, P. F. Sheedy, A. L. Weaver, E. L. Ritman

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

PURPOSE: To evaluate the ability of electron-beam computed tomography (CT) to help quantify long-term changes in coronary microvascular functional reserve in a porcine model. MATERIALS AND METHODS: Electron-beam CT-based intramyocardial blood volume and perfusion and Doppler ultrasonography (US)-based intracoronary blood flow were obtained in 13 pigs at baseline and again 3 months later. Measurements were obtained at rest and after the administration of adenosine. The short-term variation during 30 minutes of electron-beam CT measurements was assessed in nine additional pigs. RESULTS: Short-term variation of blood volume and perfusion averaged 8% and 9%, respectively, and was similar for both weight groups at rest and after adenosine administration. At rest, intracoronary blood flow, blood volume, and perfusion remained unchanged from baseline to follow-up. Long-term increases (percentage change with adenosine relative to that at rest) in blood volume and perfusion reserves were consistent with increasing intracoronary blood flow reserves. Despite these long-term changes in intracoronary blood flow, blood volume, and perfusion, the blood volume-to-perfusion relationship suggests a similar blood volume distribution among different microvascular functional components in normal porcine myocardium at both weight groups. CONCLUSION: Electron-beam CT may be of value for quantifying long-term changes in intramyocardial microvascular function.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalRadiology
Volume221
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Blood, volume
  • Computed tomography (CT), electron beam, 51.12119
  • Coronary vessels, CT, 54.12119
  • Coronary vessels, flow dynamics, 54.12119
  • Myocardium, 511.12119

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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