Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: New insight into cardiac allograft vasculopathy by optical coherence tomography

Andrew Cassar, Yoshiki Matsuo, Joerg Herrmann, Jing Li, Ryan J. Lennon, Rajiv Gulati, Lilach O Lerman, Sudhir S. Kushwaha, Amir Lerman

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

AimsCardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail to characterize CAV plaque morphology. Our aim was to characterize CAV in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT).Methods and resultsWe prospectively enrolled 53 cardiac transplant patients to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and intravascular ultrasound (IVUS). The proximal 30 mm of the LAD was divided into three segments of 10 mm each (n = 156). Segments with CAV plaque on IVUS were analysed by OCT for specific CAV morphological characteristics within the framework of three groups according to follow-up time after heart transplantation: (i) 0-3 months (n = 18), (ii) 12-36 months (n = 55), and (iii) ≥48 months (n = 83). The prevalence of atherosclerotic characteristics such as eccentric plaques, calcification, and lipid pools increased from 6, 0, and 6% in group 1 to 78, 42, and 61% in group 3, respectively (all P < 0.001). The prevalence of vulnerable plaque features such as thin-cap fibroatheroma, macrophages, and microchannels increased from 0% in group 1 to 12, 29, and 33% in group 3, respectively (P = 0.19, P = 0.006, and P = 0.003). Complicated coronary lesions such as intimal laceration, intraluminal thrombus, and layered complex plaque increased from 0% in group 1 to 18, 19, and 57% in group 3 (P = 0.009, P < 0.001, and P < 0.001). Plaque rupture was identified in 4% of group 3 segments.ConclusionThe current study gives new insight into CAV that extends far beyond the current concept of concentric and fibrosing vasculopathy, that is, the development of atherosclerosis with vulnerable plaque and complicated coronary lesions.

Original languageEnglish (US)
Pages (from-to)2610-2617
Number of pages8
JournalEuropean Heart Journal
Volume34
Issue number33
DOIs
StatePublished - Sep 7 2013

Fingerprint

Optical Coherence Tomography
Allografts
Coronary Artery Disease
Heart Transplantation
Tunica Intima
Lacerations
Atherosclerotic Plaques
Coronary Angiography
Rupture
Atherosclerosis
Coronary Vessels
Angiography
Thrombosis
Macrophages
Transplants
Lipids
Survival
Transplant Recipients

Keywords

  • Atherosclerosis
  • Cardiac allograft vasculopathy
  • Optical coherence tomography
  • Thrombus
  • Transplant
  • Vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients : New insight into cardiac allograft vasculopathy by optical coherence tomography. / Cassar, Andrew; Matsuo, Yoshiki; Herrmann, Joerg; Li, Jing; Lennon, Ryan J.; Gulati, Rajiv; Lerman, Lilach O; Kushwaha, Sudhir S.; Lerman, Amir.

In: European Heart Journal, Vol. 34, No. 33, 07.09.2013, p. 2610-2617.

Research output: Contribution to journalArticle

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title = "Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: New insight into cardiac allograft vasculopathy by optical coherence tomography",
abstract = "AimsCardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail to characterize CAV plaque morphology. Our aim was to characterize CAV in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT).Methods and resultsWe prospectively enrolled 53 cardiac transplant patients to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and intravascular ultrasound (IVUS). The proximal 30 mm of the LAD was divided into three segments of 10 mm each (n = 156). Segments with CAV plaque on IVUS were analysed by OCT for specific CAV morphological characteristics within the framework of three groups according to follow-up time after heart transplantation: (i) 0-3 months (n = 18), (ii) 12-36 months (n = 55), and (iii) ≥48 months (n = 83). The prevalence of atherosclerotic characteristics such as eccentric plaques, calcification, and lipid pools increased from 6, 0, and 6{\%} in group 1 to 78, 42, and 61{\%} in group 3, respectively (all P < 0.001). The prevalence of vulnerable plaque features such as thin-cap fibroatheroma, macrophages, and microchannels increased from 0{\%} in group 1 to 12, 29, and 33{\%} in group 3, respectively (P = 0.19, P = 0.006, and P = 0.003). Complicated coronary lesions such as intimal laceration, intraluminal thrombus, and layered complex plaque increased from 0{\%} in group 1 to 18, 19, and 57{\%} in group 3 (P = 0.009, P < 0.001, and P < 0.001). Plaque rupture was identified in 4{\%} of group 3 segments.ConclusionThe current study gives new insight into CAV that extends far beyond the current concept of concentric and fibrosing vasculopathy, that is, the development of atherosclerosis with vulnerable plaque and complicated coronary lesions.",
keywords = "Atherosclerosis, Cardiac allograft vasculopathy, Optical coherence tomography, Thrombus, Transplant, Vulnerable plaque",
author = "Andrew Cassar and Yoshiki Matsuo and Joerg Herrmann and Jing Li and Lennon, {Ryan J.} and Rajiv Gulati and Lerman, {Lilach O} and Kushwaha, {Sudhir S.} and Amir Lerman",
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T1 - Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients

T2 - New insight into cardiac allograft vasculopathy by optical coherence tomography

AU - Cassar, Andrew

AU - Matsuo, Yoshiki

AU - Herrmann, Joerg

AU - Li, Jing

AU - Lennon, Ryan J.

AU - Gulati, Rajiv

AU - Lerman, Lilach O

AU - Kushwaha, Sudhir S.

AU - Lerman, Amir

PY - 2013/9/7

Y1 - 2013/9/7

N2 - AimsCardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail to characterize CAV plaque morphology. Our aim was to characterize CAV in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT).Methods and resultsWe prospectively enrolled 53 cardiac transplant patients to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and intravascular ultrasound (IVUS). The proximal 30 mm of the LAD was divided into three segments of 10 mm each (n = 156). Segments with CAV plaque on IVUS were analysed by OCT for specific CAV morphological characteristics within the framework of three groups according to follow-up time after heart transplantation: (i) 0-3 months (n = 18), (ii) 12-36 months (n = 55), and (iii) ≥48 months (n = 83). The prevalence of atherosclerotic characteristics such as eccentric plaques, calcification, and lipid pools increased from 6, 0, and 6% in group 1 to 78, 42, and 61% in group 3, respectively (all P < 0.001). The prevalence of vulnerable plaque features such as thin-cap fibroatheroma, macrophages, and microchannels increased from 0% in group 1 to 12, 29, and 33% in group 3, respectively (P = 0.19, P = 0.006, and P = 0.003). Complicated coronary lesions such as intimal laceration, intraluminal thrombus, and layered complex plaque increased from 0% in group 1 to 18, 19, and 57% in group 3 (P = 0.009, P < 0.001, and P < 0.001). Plaque rupture was identified in 4% of group 3 segments.ConclusionThe current study gives new insight into CAV that extends far beyond the current concept of concentric and fibrosing vasculopathy, that is, the development of atherosclerosis with vulnerable plaque and complicated coronary lesions.

AB - AimsCardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail to characterize CAV plaque morphology. Our aim was to characterize CAV in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT).Methods and resultsWe prospectively enrolled 53 cardiac transplant patients to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and intravascular ultrasound (IVUS). The proximal 30 mm of the LAD was divided into three segments of 10 mm each (n = 156). Segments with CAV plaque on IVUS were analysed by OCT for specific CAV morphological characteristics within the framework of three groups according to follow-up time after heart transplantation: (i) 0-3 months (n = 18), (ii) 12-36 months (n = 55), and (iii) ≥48 months (n = 83). The prevalence of atherosclerotic characteristics such as eccentric plaques, calcification, and lipid pools increased from 6, 0, and 6% in group 1 to 78, 42, and 61% in group 3, respectively (all P < 0.001). The prevalence of vulnerable plaque features such as thin-cap fibroatheroma, macrophages, and microchannels increased from 0% in group 1 to 12, 29, and 33% in group 3, respectively (P = 0.19, P = 0.006, and P = 0.003). Complicated coronary lesions such as intimal laceration, intraluminal thrombus, and layered complex plaque increased from 0% in group 1 to 18, 19, and 57% in group 3 (P = 0.009, P < 0.001, and P < 0.001). Plaque rupture was identified in 4% of group 3 segments.ConclusionThe current study gives new insight into CAV that extends far beyond the current concept of concentric and fibrosing vasculopathy, that is, the development of atherosclerosis with vulnerable plaque and complicated coronary lesions.

KW - Atherosclerosis

KW - Cardiac allograft vasculopathy

KW - Optical coherence tomography

KW - Thrombus

KW - Transplant

KW - Vulnerable plaque

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