TY - JOUR
T1 - Coronary artery disease in giant cell arteritis
T2 - A systematic review and meta-analysis
AU - Ungprasert, Patompong
AU - Koster, Matthew J.
AU - Warrington, Kenneth J.
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Objective: To investigate the association between giant cell arteritis (GCA) and risk of coronary artery disease (CAD). Methods: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, or standardized incidence ratios with 95% confidence interval comparing CAD risk in patients with GCA versus non-GCA controls. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. Result: Six studies with 10,868 patients with GCA and 245,323 controls were identified and included in our data analysis. The pooled risk ratio of CAD in patients with GCA was 1.51 and did not achieve statistical significance (95% CI: 0.88-2.61). The statistical heterogeneity was high with an I2 of 97%. Conclusion: In contrast to other chronic systemic inflammatory disorders, our meta-analysis did not show any statistically significant increased risk of CAD among patients with GCA.
AB - Objective: To investigate the association between giant cell arteritis (GCA) and risk of coronary artery disease (CAD). Methods: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, or standardized incidence ratios with 95% confidence interval comparing CAD risk in patients with GCA versus non-GCA controls. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. Result: Six studies with 10,868 patients with GCA and 245,323 controls were identified and included in our data analysis. The pooled risk ratio of CAD in patients with GCA was 1.51 and did not achieve statistical significance (95% CI: 0.88-2.61). The statistical heterogeneity was high with an I2 of 97%. Conclusion: In contrast to other chronic systemic inflammatory disorders, our meta-analysis did not show any statistically significant increased risk of CAD among patients with GCA.
KW - Coronary artery disease
KW - Epidemiology
KW - Giant cell arteritis
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84926339762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926339762&partnerID=8YFLogxK
U2 - 10.1016/j.semarthrit.2014.10.010
DO - 10.1016/j.semarthrit.2014.10.010
M3 - Article
C2 - 25434528
AN - SCOPUS:84926339762
SN - 0049-0172
VL - 44
SP - 586
EP - 591
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 5
ER -