Coronary arterial calcification and thoracic spine mineral density in early menopause

Y. Miyabara, J. Camp, David R. Holmes III, B. Lahr, Kent R Bailey, Virginia M Miller, A. E. Kearns

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives Cardiovascular disease and osteoporosis increase in women after menopause. While aortic calcification is associated with bone loss in women, a similar relationship for coronary arterial calcification (CAC), a risk factor for coronary artery disease in women, is less clear. This study was designed to examine the relationship between CAC and volumetric bone mineral density (vBMD) in women (n = 137) who were within a median of 18 months past their last menses at screening for the Kronos Early Estrogen Prevention Study (KEEPS). Methods CAC was measured using 64-slice computed tomography; vBMD was measured from these images using the Spine Cancer Assessment program. Concentrations of osteocalcin, bone alkaline phosphatase, tartrate-resident acid phosphatase-5b and osteopontin as bone matrix protein in serum and plasma were evaluated by ELISA. Results CAC scores ranged from 0 to 327.6 Agatston Units (AU); 113 women had a score of 0 AU, 20 had a CAC score between 0 and 50 AU, and four had a CAC score >â €Š50 AU. Although not statistically significant, there was a trend toward decreasing central density of thoracic T9 with increasing CAC. On average, levels of markers of bone turnover were within the normal range but did not correlate with age or with months past menopause. Conclusions Clinically significant CAC and spine vBMD are quantifiable from the same scans within the first 3 years of menopause. Additional work is needed to determine how these measurements change with increasing age or with estrogenic treatments.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalClimacteric
Volume14
Issue number4
DOIs
StatePublished - Aug 2011

Fingerprint

Menopause
Minerals
Spine
Thorax
Bone Density
Blood Proteins
Bone and Bones
Bone Matrix
Osteopontin
Menstruation
Bone Remodeling
Osteocalcin
Acid Phosphatase
Osteoporosis
Alkaline Phosphatase
Coronary Artery Disease
Estrogens
Reference Values
Cardiovascular Diseases
Enzyme-Linked Immunosorbent Assay

Keywords

  • Bone-specific alkaline phosphatase
  • Coronary heart disease
  • Menopause
  • Osteocalcin
  • Osteopontin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Coronary arterial calcification and thoracic spine mineral density in early menopause. / Miyabara, Y.; Camp, J.; Holmes III, David R.; Lahr, B.; Bailey, Kent R; Miller, Virginia M; Kearns, A. E.

In: Climacteric, Vol. 14, No. 4, 08.2011, p. 438-444.

Research output: Contribution to journalArticle

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