Corneal transplantation

Yuri McKee, Rupa Shah, Joung Y. Kim, Timothy Olsen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Traditional full-thickness corneal transplantation, known as penetrating keratoplasty (PK), was first performed over a century ago and remains the gold standard of corneal transplantation. Penetrating keratoplasty involves replacement of all layers of the central 7–9 mm of the host cornea with allograft tissue, usually derived from eye banks. Donor corneas are harvested from 1–2 weeks prior to transplantation. Tissue or blood typing is not routinely done. The overall optical clarity, integrity of donor tissue, and donor endothelial cell density are evaluated at the eye bank. The tissue is screened for multiple infectious diseases of the donor, a procedure commonly performed for other human allograft tissues. Penetrating keratoplasty Penetrating keratoplasty usually begins with the removal of the diseased central host cornea by use of various forms of trephine. Next, the donor tissue is trephinated from the donor corneal tissue and is usually slightly oversized. The donor tissue is secured in the recipient bed using either interrupted or continuous nylon sutures. When necessary, a cataract extraction may be performed in combination with intraocular lens implantation. Monitored anesthesia care in these cases usually includes brief, intravenous sedation combined with a retrobulbar block. General anesthesia may be required for selected patients unable to be cooperative, such as children or anxious adult patients. Total surgical time is around 30–45 minutes for an experienced surgeon. Corneal graft survival at 1 year is 90% for PK. Indications for PK include haze, ectatic disease, opacities in the cornea, and corneal edema causing decreased vision or pain. In addition, infections, scars, trauma, congenital dystrophies, and corneal decompensation or injury from prior intraocular surgery are also indications.

Original languageEnglish (US)
Title of host publicationMedical Management of the Surgical Patient
Subtitle of host publicationA Textbook of Perioperative Medicine, Fifth Edition
PublisherCambridge University Press
Pages698-699
Number of pages2
ISBN (Electronic)9780511920660
ISBN (Print)9781107009165
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Corneal Transplantation
Penetrating Keratoplasty
Tissue Donors
Cornea
Eye Banks
Allografts
Blood Grouping and Crossmatching
Corneal Edema
Histocompatibility Testing
Intraocular Lens Implantation
Cataract Extraction
Nylons
Wounds and Injuries
Graft Survival
Operative Time
General Anesthesia
Sutures
Cicatrix
Communicable Diseases
Anesthesia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

McKee, Y., Shah, R., Kim, J. Y., & Olsen, T. (2010). Corneal transplantation. In Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine, Fifth Edition (pp. 698-699). Cambridge University Press. https://doi.org/10.1017/CBO9780511920660.114

Corneal transplantation. / McKee, Yuri; Shah, Rupa; Kim, Joung Y.; Olsen, Timothy.

Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine, Fifth Edition. Cambridge University Press, 2010. p. 698-699.

Research output: Chapter in Book/Report/Conference proceedingChapter

McKee, Y, Shah, R, Kim, JY & Olsen, T 2010, Corneal transplantation. in Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine, Fifth Edition. Cambridge University Press, pp. 698-699. https://doi.org/10.1017/CBO9780511920660.114
McKee Y, Shah R, Kim JY, Olsen T. Corneal transplantation. In Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine, Fifth Edition. Cambridge University Press. 2010. p. 698-699 https://doi.org/10.1017/CBO9780511920660.114
McKee, Yuri ; Shah, Rupa ; Kim, Joung Y. ; Olsen, Timothy. / Corneal transplantation. Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine, Fifth Edition. Cambridge University Press, 2010. pp. 698-699
@inbook{09a1dbf2b4c14a4ab2a34c16531743af,
title = "Corneal transplantation",
abstract = "Traditional full-thickness corneal transplantation, known as penetrating keratoplasty (PK), was first performed over a century ago and remains the gold standard of corneal transplantation. Penetrating keratoplasty involves replacement of all layers of the central 7–9 mm of the host cornea with allograft tissue, usually derived from eye banks. Donor corneas are harvested from 1–2 weeks prior to transplantation. Tissue or blood typing is not routinely done. The overall optical clarity, integrity of donor tissue, and donor endothelial cell density are evaluated at the eye bank. The tissue is screened for multiple infectious diseases of the donor, a procedure commonly performed for other human allograft tissues. Penetrating keratoplasty Penetrating keratoplasty usually begins with the removal of the diseased central host cornea by use of various forms of trephine. Next, the donor tissue is trephinated from the donor corneal tissue and is usually slightly oversized. The donor tissue is secured in the recipient bed using either interrupted or continuous nylon sutures. When necessary, a cataract extraction may be performed in combination with intraocular lens implantation. Monitored anesthesia care in these cases usually includes brief, intravenous sedation combined with a retrobulbar block. General anesthesia may be required for selected patients unable to be cooperative, such as children or anxious adult patients. Total surgical time is around 30–45 minutes for an experienced surgeon. Corneal graft survival at 1 year is 90{\%} for PK. Indications for PK include haze, ectatic disease, opacities in the cornea, and corneal edema causing decreased vision or pain. In addition, infections, scars, trauma, congenital dystrophies, and corneal decompensation or injury from prior intraocular surgery are also indications.",
author = "Yuri McKee and Rupa Shah and Kim, {Joung Y.} and Timothy Olsen",
year = "2010",
month = "1",
day = "1",
doi = "10.1017/CBO9780511920660.114",
language = "English (US)",
isbn = "9781107009165",
pages = "698--699",
booktitle = "Medical Management of the Surgical Patient",
publisher = "Cambridge University Press",
address = "United States",

}

TY - CHAP

T1 - Corneal transplantation

AU - McKee, Yuri

AU - Shah, Rupa

AU - Kim, Joung Y.

AU - Olsen, Timothy

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Traditional full-thickness corneal transplantation, known as penetrating keratoplasty (PK), was first performed over a century ago and remains the gold standard of corneal transplantation. Penetrating keratoplasty involves replacement of all layers of the central 7–9 mm of the host cornea with allograft tissue, usually derived from eye banks. Donor corneas are harvested from 1–2 weeks prior to transplantation. Tissue or blood typing is not routinely done. The overall optical clarity, integrity of donor tissue, and donor endothelial cell density are evaluated at the eye bank. The tissue is screened for multiple infectious diseases of the donor, a procedure commonly performed for other human allograft tissues. Penetrating keratoplasty Penetrating keratoplasty usually begins with the removal of the diseased central host cornea by use of various forms of trephine. Next, the donor tissue is trephinated from the donor corneal tissue and is usually slightly oversized. The donor tissue is secured in the recipient bed using either interrupted or continuous nylon sutures. When necessary, a cataract extraction may be performed in combination with intraocular lens implantation. Monitored anesthesia care in these cases usually includes brief, intravenous sedation combined with a retrobulbar block. General anesthesia may be required for selected patients unable to be cooperative, such as children or anxious adult patients. Total surgical time is around 30–45 minutes for an experienced surgeon. Corneal graft survival at 1 year is 90% for PK. Indications for PK include haze, ectatic disease, opacities in the cornea, and corneal edema causing decreased vision or pain. In addition, infections, scars, trauma, congenital dystrophies, and corneal decompensation or injury from prior intraocular surgery are also indications.

AB - Traditional full-thickness corneal transplantation, known as penetrating keratoplasty (PK), was first performed over a century ago and remains the gold standard of corneal transplantation. Penetrating keratoplasty involves replacement of all layers of the central 7–9 mm of the host cornea with allograft tissue, usually derived from eye banks. Donor corneas are harvested from 1–2 weeks prior to transplantation. Tissue or blood typing is not routinely done. The overall optical clarity, integrity of donor tissue, and donor endothelial cell density are evaluated at the eye bank. The tissue is screened for multiple infectious diseases of the donor, a procedure commonly performed for other human allograft tissues. Penetrating keratoplasty Penetrating keratoplasty usually begins with the removal of the diseased central host cornea by use of various forms of trephine. Next, the donor tissue is trephinated from the donor corneal tissue and is usually slightly oversized. The donor tissue is secured in the recipient bed using either interrupted or continuous nylon sutures. When necessary, a cataract extraction may be performed in combination with intraocular lens implantation. Monitored anesthesia care in these cases usually includes brief, intravenous sedation combined with a retrobulbar block. General anesthesia may be required for selected patients unable to be cooperative, such as children or anxious adult patients. Total surgical time is around 30–45 minutes for an experienced surgeon. Corneal graft survival at 1 year is 90% for PK. Indications for PK include haze, ectatic disease, opacities in the cornea, and corneal edema causing decreased vision or pain. In addition, infections, scars, trauma, congenital dystrophies, and corneal decompensation or injury from prior intraocular surgery are also indications.

UR - http://www.scopus.com/inward/record.url?scp=84923519105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923519105&partnerID=8YFLogxK

U2 - 10.1017/CBO9780511920660.114

DO - 10.1017/CBO9780511920660.114

M3 - Chapter

AN - SCOPUS:84923519105

SN - 9781107009165

SP - 698

EP - 699

BT - Medical Management of the Surgical Patient

PB - Cambridge University Press

ER -