Copper Deficiency Myelopathy

Neeraj Kumar, Brian Crum, Ronald Carl Petersen, Steven A. Vernino, J. Eric Ahlskog

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background: In humans, Menkes disease is the well-recognized neurological disorder due to inherited copper deficiency. Myelopathy due to acquired copper deficiency is not a well-recognized entity in humans, although myelopathy due to copper deficiency is well documented in some animal species. Patients: We describe 3 patients who developed a progressive spastic-ataxic gait with proprioceptive deficits. All patients had a severe reduction in serum ceruloplasmin and copper levels. Results: All patients had evidence of posterior column dysfunction clinically and on somatosensory evoked potential studies. Two had a signal change in the posterior column on magnetic resonance imaging of the spinal cord. Conclusions: Patients presenting with otherwise unexplained myelopathies should have their serum ceruloplasmin level measured.

Original languageEnglish (US)
Pages (from-to)762-766
Number of pages5
JournalArchives of Neurology
Volume61
Issue number5
DOIs
StatePublished - May 2004

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Spinal Cord Diseases
Copper
Ceruloplasmin
Menkes Kinky Hair Syndrome
Neurologic Gait Disorders
Somatosensory Evoked Potentials
Nervous System Diseases
Serum
Spinal Cord
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kumar, N., Crum, B., Petersen, R. C., Vernino, S. A., & Ahlskog, J. E. (2004). Copper Deficiency Myelopathy. Archives of Neurology, 61(5), 762-766. https://doi.org/10.1001/archneur.61.5.762

Copper Deficiency Myelopathy. / Kumar, Neeraj; Crum, Brian; Petersen, Ronald Carl; Vernino, Steven A.; Ahlskog, J. Eric.

In: Archives of Neurology, Vol. 61, No. 5, 05.2004, p. 762-766.

Research output: Contribution to journalArticle

Kumar, N, Crum, B, Petersen, RC, Vernino, SA & Ahlskog, JE 2004, 'Copper Deficiency Myelopathy', Archives of Neurology, vol. 61, no. 5, pp. 762-766. https://doi.org/10.1001/archneur.61.5.762
Kumar N, Crum B, Petersen RC, Vernino SA, Ahlskog JE. Copper Deficiency Myelopathy. Archives of Neurology. 2004 May;61(5):762-766. https://doi.org/10.1001/archneur.61.5.762
Kumar, Neeraj ; Crum, Brian ; Petersen, Ronald Carl ; Vernino, Steven A. ; Ahlskog, J. Eric. / Copper Deficiency Myelopathy. In: Archives of Neurology. 2004 ; Vol. 61, No. 5. pp. 762-766.
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