Convection-enhanced delivery for H3K27M diffuse midline glioma: How can we efficaciously modulate the blood-brain barrier?

Julian S. Rechberger; Erica A. Power; David J. Daniels

doi:10.4155/tde-2021-0026

Convection-enhanced delivery for H3K27M diffuse midline glioma: How can we efficaciously modulate the blood-brain barrier?

Julian S. Rechberger, Erica A. Power, David J. Daniels

Neurosurgery

Research output: Contribution to journal › Article › peer-review

Abstract

Nanoparticle formulations are one potential solution to modulate the BBB and brain extracellular environment in a way that decreases drug efflux and enhances retention time, distribution volume and cellular uptake to attain optimal drug concentrations in DMG.

Original language	English (US)
Pages (from-to)	419-422
Number of pages	4
Journal	Therapeutic Delivery
Volume	12
Issue number	6
DOIs	https://doi.org/10.4155/tde-2021-0026
State	Published - Jun 2021

Keywords

blood-brain barrier
clearance
convection-enhanced delivery
diffuse midline glioma
efflux
half-life
toxicity
volume of distribution

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.4155/tde-2021-0026

Cite this

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title = "Convection-enhanced delivery for H3K27M diffuse midline glioma: How can we efficaciously modulate the blood-brain barrier?",

abstract = "Nanoparticle formulations are one potential solution to modulate the BBB and brain extracellular environment in a way that decreases drug efflux and enhances retention time, distribution volume and cellular uptake to attain optimal drug concentrations in DMG.",

keywords = "blood-brain barrier, clearance, convection-enhanced delivery, diffuse midline glioma, efflux, half-life, toxicity, volume of distribution",

author = "Rechberger, {Julian S.} and Power, {Erica A.} and Daniels, {David J.}",

year = "2021",

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AU - Daniels, David J.

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AB - Nanoparticle formulations are one potential solution to modulate the BBB and brain extracellular environment in a way that decreases drug efflux and enhances retention time, distribution volume and cellular uptake to attain optimal drug concentrations in DMG.

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KW - clearance

KW - convection-enhanced delivery

KW - diffuse midline glioma

KW - efflux

KW - half-life

KW - toxicity

KW - volume of distribution

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Convection-enhanced delivery for H3K27M diffuse midline glioma: How can we efficaciously modulate the blood-brain barrier?

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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