Contribution of the innate immune system to autoimmune myocarditis: A role for complement

Ziya Kaya, Marina Afanasyeva, Yan Wang, K. Malte Dohmen, Jens Schlichting, Theresa Tretter, DeLisa Fairweather, V. Michael Holers, Noel R. Rose

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Myocarditis is a principal cause of heart disease among young adults and is often a precursor of heart failure due to dilated cardiomyopathy. We show here that complement is critical for the induction of experimental autoimmune myocarditis and that it acts through complement receptor type I (CR1) and type 2 (CR2). We also found a subset of CD44hiCD62Llo T cells that expresses CR1 and CR2 and propose that both receptors are involved in the expression of B and T cell activation markers, T cell proliferation and cytokine production. These findings provide a mechanism by which activated complement, a key product of the innate immune response, modulates the induction of an autoimmune disease.

Original languageEnglish (US)
Pages (from-to)739-745
Number of pages7
JournalNature Immunology
Volume2
Issue number8
DOIs
StatePublished - 2001
Externally publishedYes

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Myocarditis
Immune System
T-Lymphocytes
Complement Receptors
Dilated Cardiomyopathy
T-Lymphocyte Subsets
Innate Immunity
Autoimmune Diseases
Young Adult
Heart Diseases
B-Lymphocytes
Heart Failure
Cell Proliferation
Cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

Kaya, Z., Afanasyeva, M., Wang, Y., Dohmen, K. M., Schlichting, J., Tretter, T., ... Rose, N. R. (2001). Contribution of the innate immune system to autoimmune myocarditis: A role for complement. Nature Immunology, 2(8), 739-745. https://doi.org/10.1038/90686

Contribution of the innate immune system to autoimmune myocarditis : A role for complement. / Kaya, Ziya; Afanasyeva, Marina; Wang, Yan; Dohmen, K. Malte; Schlichting, Jens; Tretter, Theresa; Fairweather, DeLisa; Holers, V. Michael; Rose, Noel R.

In: Nature Immunology, Vol. 2, No. 8, 2001, p. 739-745.

Research output: Contribution to journalArticle

Kaya, Z, Afanasyeva, M, Wang, Y, Dohmen, KM, Schlichting, J, Tretter, T, Fairweather, D, Holers, VM & Rose, NR 2001, 'Contribution of the innate immune system to autoimmune myocarditis: A role for complement', Nature Immunology, vol. 2, no. 8, pp. 739-745. https://doi.org/10.1038/90686
Kaya Z, Afanasyeva M, Wang Y, Dohmen KM, Schlichting J, Tretter T et al. Contribution of the innate immune system to autoimmune myocarditis: A role for complement. Nature Immunology. 2001;2(8):739-745. https://doi.org/10.1038/90686
Kaya, Ziya ; Afanasyeva, Marina ; Wang, Yan ; Dohmen, K. Malte ; Schlichting, Jens ; Tretter, Theresa ; Fairweather, DeLisa ; Holers, V. Michael ; Rose, Noel R. / Contribution of the innate immune system to autoimmune myocarditis : A role for complement. In: Nature Immunology. 2001 ; Vol. 2, No. 8. pp. 739-745.
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