Contribution of ascites to impaired gastric function and nutritional intake in patients with cirrhosis and ascites

Bashar A. Aqel, James S. Scolapio, Rolland Dickson, Duane D. Burton, Ernest P. Bouras

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background & Aims: Protein calorie malnutrition and weight loss are common among patients with cirrhosis and ascites. The cause of these symptoms is unclear, with several putative mechanisms proposed. The primary aims of this study were to compare gastric volumes and accommodation between patients with cirrhosis complicated by ascites and healthy controls, and to evaluate the effect of large-volume paracentesis in the patient group. Methods: Patients with cirrhosis and ascites underwent assessment of gastric volumes as measured by single-photon emission computed tomography, gastric sensation assessed by a validated nutrient drink test, and a 3-day assessment of caloric intake before and after large-volume paracentesis. Age- and sex-adjusted linear regression models were used to compare gastric volumes and accommodation ratios between patients and healthy volunteers. Paired Wilcoxon rank-sum tests were used to compare gastric measures before and after paracentesis among the patient group. Results: Fifteen patients (median age, 54 y) were compared with 112 healthy (age- and sex-matched) controls. Median postprandial gastric volumes (627 mL patients vs 721 healthy controls) and gastric accommodation were reduced significantly in patients compared with healthy controls (P = .02 and .006, respectively). After paracentesis: (1) fasting gastric volumes were increased (median 312 mL post- vs 241 mL pre-, P = .04), (2) patients tolerated ingestion of larger maximum volumes (median 964 mL post- vs 738 mL pre-, P = .04), and (3) caloric intake was increased (median 34% kcal post- vs 3110 kcal pre-, P = .005). Conclusions: Postprandial gastric volumes and accommodation ratios are reduced in patients with cirrhosis and ascites compared with healthy controls. In addition, large-volume paracentesis increases fasting gastric volumes, volumes ingested until maximal satiation, and caloric intake.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
JournalClinical Gastroenterology and Hepatology
Volume3
Issue number11
DOIs
StatePublished - Nov 2005

Fingerprint

Ascites
Stomach
Fibrosis
Paracentesis
Energy Intake
Nonparametric Statistics
Linear Models
Fasting
Satiation
Protein-Energy Malnutrition
Single-Photon Emission-Computed Tomography
Weight Loss
Healthy Volunteers
Eating
Food

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Contribution of ascites to impaired gastric function and nutritional intake in patients with cirrhosis and ascites. / Aqel, Bashar A.; Scolapio, James S.; Dickson, Rolland; Burton, Duane D.; Bouras, Ernest P.

In: Clinical Gastroenterology and Hepatology, Vol. 3, No. 11, 11.2005, p. 1095-1100.

Research output: Contribution to journalArticle

Aqel, Bashar A. ; Scolapio, James S. ; Dickson, Rolland ; Burton, Duane D. ; Bouras, Ernest P. / Contribution of ascites to impaired gastric function and nutritional intake in patients with cirrhosis and ascites. In: Clinical Gastroenterology and Hepatology. 2005 ; Vol. 3, No. 11. pp. 1095-1100.
@article{442fed24edca4067939d7ba31819e8d1,
title = "Contribution of ascites to impaired gastric function and nutritional intake in patients with cirrhosis and ascites",
abstract = "Background & Aims: Protein calorie malnutrition and weight loss are common among patients with cirrhosis and ascites. The cause of these symptoms is unclear, with several putative mechanisms proposed. The primary aims of this study were to compare gastric volumes and accommodation between patients with cirrhosis complicated by ascites and healthy controls, and to evaluate the effect of large-volume paracentesis in the patient group. Methods: Patients with cirrhosis and ascites underwent assessment of gastric volumes as measured by single-photon emission computed tomography, gastric sensation assessed by a validated nutrient drink test, and a 3-day assessment of caloric intake before and after large-volume paracentesis. Age- and sex-adjusted linear regression models were used to compare gastric volumes and accommodation ratios between patients and healthy volunteers. Paired Wilcoxon rank-sum tests were used to compare gastric measures before and after paracentesis among the patient group. Results: Fifteen patients (median age, 54 y) were compared with 112 healthy (age- and sex-matched) controls. Median postprandial gastric volumes (627 mL patients vs 721 healthy controls) and gastric accommodation were reduced significantly in patients compared with healthy controls (P = .02 and .006, respectively). After paracentesis: (1) fasting gastric volumes were increased (median 312 mL post- vs 241 mL pre-, P = .04), (2) patients tolerated ingestion of larger maximum volumes (median 964 mL post- vs 738 mL pre-, P = .04), and (3) caloric intake was increased (median 34{\%} kcal post- vs 3110 kcal pre-, P = .005). Conclusions: Postprandial gastric volumes and accommodation ratios are reduced in patients with cirrhosis and ascites compared with healthy controls. In addition, large-volume paracentesis increases fasting gastric volumes, volumes ingested until maximal satiation, and caloric intake.",
author = "Aqel, {Bashar A.} and Scolapio, {James S.} and Rolland Dickson and Burton, {Duane D.} and Bouras, {Ernest P.}",
year = "2005",
month = "11",
doi = "10.1016/S1542-3565(05)00531-8",
language = "English (US)",
volume = "3",
pages = "1095--1100",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "11",

}

TY - JOUR

T1 - Contribution of ascites to impaired gastric function and nutritional intake in patients with cirrhosis and ascites

AU - Aqel, Bashar A.

AU - Scolapio, James S.

AU - Dickson, Rolland

AU - Burton, Duane D.

AU - Bouras, Ernest P.

PY - 2005/11

Y1 - 2005/11

N2 - Background & Aims: Protein calorie malnutrition and weight loss are common among patients with cirrhosis and ascites. The cause of these symptoms is unclear, with several putative mechanisms proposed. The primary aims of this study were to compare gastric volumes and accommodation between patients with cirrhosis complicated by ascites and healthy controls, and to evaluate the effect of large-volume paracentesis in the patient group. Methods: Patients with cirrhosis and ascites underwent assessment of gastric volumes as measured by single-photon emission computed tomography, gastric sensation assessed by a validated nutrient drink test, and a 3-day assessment of caloric intake before and after large-volume paracentesis. Age- and sex-adjusted linear regression models were used to compare gastric volumes and accommodation ratios between patients and healthy volunteers. Paired Wilcoxon rank-sum tests were used to compare gastric measures before and after paracentesis among the patient group. Results: Fifteen patients (median age, 54 y) were compared with 112 healthy (age- and sex-matched) controls. Median postprandial gastric volumes (627 mL patients vs 721 healthy controls) and gastric accommodation were reduced significantly in patients compared with healthy controls (P = .02 and .006, respectively). After paracentesis: (1) fasting gastric volumes were increased (median 312 mL post- vs 241 mL pre-, P = .04), (2) patients tolerated ingestion of larger maximum volumes (median 964 mL post- vs 738 mL pre-, P = .04), and (3) caloric intake was increased (median 34% kcal post- vs 3110 kcal pre-, P = .005). Conclusions: Postprandial gastric volumes and accommodation ratios are reduced in patients with cirrhosis and ascites compared with healthy controls. In addition, large-volume paracentesis increases fasting gastric volumes, volumes ingested until maximal satiation, and caloric intake.

AB - Background & Aims: Protein calorie malnutrition and weight loss are common among patients with cirrhosis and ascites. The cause of these symptoms is unclear, with several putative mechanisms proposed. The primary aims of this study were to compare gastric volumes and accommodation between patients with cirrhosis complicated by ascites and healthy controls, and to evaluate the effect of large-volume paracentesis in the patient group. Methods: Patients with cirrhosis and ascites underwent assessment of gastric volumes as measured by single-photon emission computed tomography, gastric sensation assessed by a validated nutrient drink test, and a 3-day assessment of caloric intake before and after large-volume paracentesis. Age- and sex-adjusted linear regression models were used to compare gastric volumes and accommodation ratios between patients and healthy volunteers. Paired Wilcoxon rank-sum tests were used to compare gastric measures before and after paracentesis among the patient group. Results: Fifteen patients (median age, 54 y) were compared with 112 healthy (age- and sex-matched) controls. Median postprandial gastric volumes (627 mL patients vs 721 healthy controls) and gastric accommodation were reduced significantly in patients compared with healthy controls (P = .02 and .006, respectively). After paracentesis: (1) fasting gastric volumes were increased (median 312 mL post- vs 241 mL pre-, P = .04), (2) patients tolerated ingestion of larger maximum volumes (median 964 mL post- vs 738 mL pre-, P = .04), and (3) caloric intake was increased (median 34% kcal post- vs 3110 kcal pre-, P = .005). Conclusions: Postprandial gastric volumes and accommodation ratios are reduced in patients with cirrhosis and ascites compared with healthy controls. In addition, large-volume paracentesis increases fasting gastric volumes, volumes ingested until maximal satiation, and caloric intake.

UR - http://www.scopus.com/inward/record.url?scp=27644539647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644539647&partnerID=8YFLogxK

U2 - 10.1016/S1542-3565(05)00531-8

DO - 10.1016/S1542-3565(05)00531-8

M3 - Article

C2 - 16271340

AN - SCOPUS:27644539647

VL - 3

SP - 1095

EP - 1100

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 11

ER -