Contralateral testicular relapse after prophylactic radiation in a patient with primary testicular diffuse large B-cell lymphoma

Amber L. Conrad, Ronald S. Go

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Prophylactic radiation to the contralateral uninvolved testicle has become a standard practice in the treatment of primary testicular lymphoma. While it is generally felt to be very effective, its failure rate is unknown. We describe a patient with primary testicular diffuse large B-cell lymphoma, who developed recurrent disease in the contralateral testicle despite receiving prophylactic testicular radiation, central nervous system prophylaxis, and anthracycline-based chemo-immunotherapy. Review of the literature shows that the testicular failure rate after prophylactic radiation may be unexpectedly high at 10% or more. We put forward hypotheses on testicular relapse and discuss potential alternative preventive strategies.

Original languageEnglish (US)
Pages (from-to)603-605
Number of pages3
JournalEuropean Journal of Haematology
Volume83
Issue number6
DOIs
StatePublished - Dec 1 2009

Keywords

  • Diffuse large B-cell lymphoma
  • Prophylactic testicular radiation
  • Testicular relapse

ASJC Scopus subject areas

  • Hematology

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