Continuous growth of mean tumor diameter in a subset of grade II gliomas

Emmanuel Mandonnet; Jean Yves Delattre; Marie Laure Tanguy; Kristin R. Swanson; Antoine F. Carpentier; Hugues Duffau; Philippe Cornu; Rémy Van Effenterre; Ellsworth C. Alvord; Laurent Capelle

doi:10.1002/ana.10528

Continuous growth of mean tumor diameter in a subset of grade II gliomas

Emmanuel Mandonnet, Jean Yves Delattre, Marie Laure Tanguy, Kristin R. Swanson, Antoine F. Carpentier, Hugues Duffau, Philippe Cornu, Rémy Van Effenterre, Ellsworth C. Alvord, Laurent Capelle

Neurologic Surgery

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343 Scopus citations

Abstract

Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.

Original language	English (US)
Pages (from-to)	524-528
Number of pages	5
Journal	Annals of neurology
Volume	53
Issue number	4
DOIs	https://doi.org/10.1002/ana.10528
State	Published - Apr 1 2003

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.",

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T1 - Continuous growth of mean tumor diameter in a subset of grade II gliomas

AU - Mandonnet, Emmanuel

AU - Delattre, Jean Yves

AU - Tanguy, Marie Laure

AU - Swanson, Kristin R.

AU - Carpentier, Antoine F.

AU - Duffau, Hugues

AU - Cornu, Philippe

AU - Van Effenterre, Rémy

AU - Alvord, Ellsworth C.

AU - Capelle, Laurent

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N2 - Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.

AB - Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8-4.4mm/year). Untreated low-grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow-up.

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Continuous growth of mean tumor diameter in a subset of grade II gliomas

Abstract

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