Consistency of HLA associations between two independent measles vaccine cohorts: A replication study

Inna G. Ovsyannikova, V. Shane Pankratz, Robert A. Vierkant, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Associations between HLA genotypes and measles vaccine humoral and cellular immune responses were examined to better understand immunogenetic drivers of vaccine response. Two independent study cohorts of healthy schoolchildren were examined: cohort one, 346 children between 12 and 18 years of age; and cohort two, 388 children between 11 and 19 years of age. All received two age-appropriate doses of measles-containing vaccine. The purpose of this study was to identify and replicate associations between HLA genes and immune responses following measles vaccination found in our first cohort. Associations of comparable magnitudes and with similar p-values were observed between B*3503 (1st cohort p= 0.01; 2nd cohort p= 0.07), DQA1*0201 (1st cohort p= 0.03; 2nd cohort p= 0.03), DQB1cellular0303 (1st cohort p= 0.10; 2 cohort p= 0.02), DQB1*0602 (1st cohort p= 0.07; 2nd cohort p= 0.10), and DRB1*0701 (1st cohort p= 0.03; 2nd cohort p= 0.07) alleles and measles-specific antibody levels. Suggestive, yet consistent, associations were observed between the B7 (1st cohort p= 0.01; 2nd cohort p= 0.08) supertype and higher measles antibody levels in both cohorts. Also, in both cohorts, the B*0801 and DRB1*0301 alleles, C*0802 and DPA1*0202 alleles, and DRB1*1303 alleles displayed consistent associations with variations in IFN-γ, IL-2 and IL-10 secretion, respectively. This study emphasizes the importance of replicating HLA associations with measles vaccine-induced humoral and cellular immune responses and increases confidence in the results. These data will inform strategies for functional studies and novel vaccine development, including epitope-based measles vaccines. This is the first HLA association replication study with measles vaccine-specific immune responses to date.

Original languageEnglish (US)
Pages (from-to)2146-2152
Number of pages7
JournalVaccine
Volume30
Issue number12
DOIs
StatePublished - Mar 9 2012

Fingerprint

Measles Vaccine
vaccines
Measles
Alleles
alleles
Humoral Immunity
Cellular Immunity
humoral immunity
cell-mediated immunity
Vaccines
Immunogenetics
immune response
immunogenetics
Antibodies
antibodies
school children
Interleukin-10
vaccine development
Interleukin-2
Epitopes

Keywords

  • Antibodies
  • Cytokines
  • Haplotypes
  • HLA genotypes
  • Measles vaccine
  • Replication study

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Ovsyannikova, I. G., Shane Pankratz, V., Vierkant, R. A., Jacobson, R. M., & Poland, G. A. (2012). Consistency of HLA associations between two independent measles vaccine cohorts: A replication study. Vaccine, 30(12), 2146-2152. https://doi.org/10.1016/j.vaccine.2012.01.038

Consistency of HLA associations between two independent measles vaccine cohorts : A replication study. / Ovsyannikova, Inna G.; Shane Pankratz, V.; Vierkant, Robert A.; Jacobson, Robert M.; Poland, Gregory A.

In: Vaccine, Vol. 30, No. 12, 09.03.2012, p. 2146-2152.

Research output: Contribution to journalArticle

Ovsyannikova, IG, Shane Pankratz, V, Vierkant, RA, Jacobson, RM & Poland, GA 2012, 'Consistency of HLA associations between two independent measles vaccine cohorts: A replication study', Vaccine, vol. 30, no. 12, pp. 2146-2152. https://doi.org/10.1016/j.vaccine.2012.01.038
Ovsyannikova IG, Shane Pankratz V, Vierkant RA, Jacobson RM, Poland GA. Consistency of HLA associations between two independent measles vaccine cohorts: A replication study. Vaccine. 2012 Mar 9;30(12):2146-2152. https://doi.org/10.1016/j.vaccine.2012.01.038
Ovsyannikova, Inna G. ; Shane Pankratz, V. ; Vierkant, Robert A. ; Jacobson, Robert M. ; Poland, Gregory A. / Consistency of HLA associations between two independent measles vaccine cohorts : A replication study. In: Vaccine. 2012 ; Vol. 30, No. 12. pp. 2146-2152.
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