Consequences of exercise-induced respiratory muscle work

Jerome A. Dempsey, Lee Romer, Joshua Rodman, Jordan D Miller, Curtis Smith

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

We briefly review the evidence for a hypothesis, which links the ventilatory response to heavy intensity, sustained exercise-to-exercise performance limitation in health. A key step in this linkage is a respiratory muscle fatigue-induced metaboreflex, which increases sympathetic vasoconstrictor outflow, causing reduced blood flow to locomotor muscles and locomotor muscle fatigue. In turn, the limb fatigue comprises an important dual contribution to both peripheral and central fatigue mechanisms, which contribute to limiting exercise performance. Clinical implications for respiratory limitations to exercise in patients with chronic obstructive lung disease (COPD) and chronic heart failure (CHF) are discussed and key unresolved problems are outlined.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalRespiratory Physiology and Neurobiology
Volume151
Issue number2-3
DOIs
StatePublished - Apr 28 2006
Externally publishedYes

Fingerprint

Respiratory Muscles
Exercise
Muscle Fatigue
Chronic Obstructive Pulmonary Disease
Fatigue
Vasoconstrictor Agents
Extremities
Heart Failure
Muscles
Health

Keywords

  • Blood flow
  • Diaphragm
  • Exercise
  • Fatigue
  • Respiratory muscle work

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Dempsey, J. A., Romer, L., Rodman, J., Miller, J. D., & Smith, C. (2006). Consequences of exercise-induced respiratory muscle work. Respiratory Physiology and Neurobiology, 151(2-3), 242-250. https://doi.org/10.1016/j.resp.2005.12.015

Consequences of exercise-induced respiratory muscle work. / Dempsey, Jerome A.; Romer, Lee; Rodman, Joshua; Miller, Jordan D; Smith, Curtis.

In: Respiratory Physiology and Neurobiology, Vol. 151, No. 2-3, 28.04.2006, p. 242-250.

Research output: Contribution to journalArticle

Dempsey, JA, Romer, L, Rodman, J, Miller, JD & Smith, C 2006, 'Consequences of exercise-induced respiratory muscle work', Respiratory Physiology and Neurobiology, vol. 151, no. 2-3, pp. 242-250. https://doi.org/10.1016/j.resp.2005.12.015
Dempsey, Jerome A. ; Romer, Lee ; Rodman, Joshua ; Miller, Jordan D ; Smith, Curtis. / Consequences of exercise-induced respiratory muscle work. In: Respiratory Physiology and Neurobiology. 2006 ; Vol. 151, No. 2-3. pp. 242-250.
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