Consensus statement on the diagnosis of multiple system atrophy

S. Gilman; P. A. Low; N. Quinn; A. Albanese; Y. Ben-Shlomo; C. J. Fowler; H. Kaufmann; T. Klockgether; A. E. Lang; P. L. Lantos; I. Litvan; C. J. Mathias; E. Oliver; D. Robertson; I. Schatz; G. K. Wenning

doi:10.1016/S0022-510X(98)00304-9

Consensus statement on the diagnosis of multiple system atrophy

S. Gilman, P. A. Low, N. Quinn, A. Albanese, Y. Ben-Shlomo, C. J. Fowler, H. Kaufmann, T. Klockgether, A. E. Lang, P. L. Lantos, I. Litvan, C. J. Mathias, E. Oliver, D. Robertson, I. Schatz, G. K. Wenning

Neurology

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921 Scopus citations

Abstract

We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate other domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.

Original language	English (US)
Pages (from-to)	94-98
Number of pages	5
Journal	Journal of the neurological sciences
Volume	163
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(98)00304-9
State	Published - Feb 1 1999

Keywords

Autonomic insufficiency
Cerebellar ataxia
Glial cytoplasmic inclusion
Multiple system atrophy
Parkinsonism
Urinary dysfunction

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/S0022-510X(98)00304-9

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Gilman, S., Low, P. A., Quinn, N., Albanese, A., Ben-Shlomo, Y., Fowler, C. J., Kaufmann, H., Klockgether, T., Lang, A. E., Lantos, P. L., Litvan, I., Mathias, C. J., Oliver, E., Robertson, D., Schatz, I., & Wenning, G. K. (1999). Consensus statement on the diagnosis of multiple system atrophy. Journal of the neurological sciences, 163(1), 94-98. https://doi.org/10.1016/S0022-510X(98)00304-9

Gilman, S, Low, PA, Quinn, N, Albanese, A, Ben-Shlomo, Y, Fowler, CJ, Kaufmann, H, Klockgether, T, Lang, AE, Lantos, PL, Litvan, I, Mathias, CJ, Oliver, E, Robertson, D, Schatz, I & Wenning, GK 1999, 'Consensus statement on the diagnosis of multiple system atrophy', Journal of the neurological sciences, vol. 163, no. 1, pp. 94-98. https://doi.org/10.1016/S0022-510X(98)00304-9

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title = "Consensus statement on the diagnosis of multiple system atrophy",

abstract = "We report the results of a consensus conference on the diagnosis of multiple system atrophy (MSA). We describe the clinical features of the disease, which include four domains: autonomic failure/urinary dysfunction, parkinsonism and cerebellar ataxia, and corticospinal dysfunction. We set criteria to define the relative importance of these features. The diagnosis of possible MSA requires one criterion plus two features from separate other domains. The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation.",

keywords = "Autonomic insufficiency, Cerebellar ataxia, Glial cytoplasmic inclusion, Multiple system atrophy, Parkinsonism, Urinary dysfunction",

author = "S. Gilman and Low, {P. A.} and N. Quinn and A. Albanese and Y. Ben-Shlomo and Fowler, {C. J.} and H. Kaufmann and T. Klockgether and Lang, {A. E.} and Lantos, {P. L.} and I. Litvan and Mathias, {C. J.} and E. Oliver and D. Robertson and I. Schatz and Wenning, {G. K.}",

note = "Funding Information: This conference was supported in part by the Office of Rare Diseases and the National Institute of Neurological Disorders and Stroke, National Institutes of Health; Glaxo Wellcome, Inc.; Hoechst Marion Roussell; and Roberts Pharmaceutical Corporation.",

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AU - Gilman, S.

AU - Low, P. A.

AU - Quinn, N.

AU - Albanese, A.

AU - Ben-Shlomo, Y.

AU - Fowler, C. J.

AU - Kaufmann, H.

AU - Klockgether, T.

AU - Lang, A. E.

AU - Lantos, P. L.

AU - Litvan, I.

AU - Mathias, C. J.

AU - Oliver, E.

AU - Robertson, D.

AU - Schatz, I.

AU - Wenning, G. K.

N1 - Funding Information: This conference was supported in part by the Office of Rare Diseases and the National Institute of Neurological Disorders and Stroke, National Institutes of Health; Glaxo Wellcome, Inc.; Hoechst Marion Roussell; and Roberts Pharmaceutical Corporation.

PY - 1999/2/1

Y1 - 1999/2/1

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KW - Autonomic insufficiency

KW - Cerebellar ataxia

KW - Glial cytoplasmic inclusion

KW - Multiple system atrophy

KW - Parkinsonism

KW - Urinary dysfunction

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Consensus statement on the diagnosis of multiple system atrophy

Abstract

Keywords

ASJC Scopus subject areas

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