TY - JOUR
T1 - Consensus report on impulsive aggression as a symptom across diagnostic categories in child psychiatry
T2 - Implications for medication studies
AU - Jensen, Peter S.
AU - Youngstrom, Eric A.
AU - Steiner, Hans
AU - Findling, Robert L.
AU - Meyer, Roger E.
AU - Malone, Richard P.
AU - Carlson, Gabrielle A.
AU - Coccaro, Emil F.
AU - Aman, Michael G.
AU - Blair, James
AU - Dougherty, Donald
AU - Ferris, Craig
AU - Flynn, Laurie
AU - Green, Evelyn
AU - Hoagwood, Kimberly
AU - Hutchinson, Janice
AU - Laughren, Tom
AU - Leve, Leslie D.
AU - Novins, Douglas K.
AU - Vitiello, Benedetto
PY - 2007/3
Y1 - 2007/3
N2 - OBJECTIVE: To determine whether impulsive aggression (IA) is a meaningful clinical construct and to ascertain whether it is sufficiently similar across diagnostic categories, such that parallel studies across disorders might constitute appropriate evidence for pursuing indications. If so, how should IA be assessed, pharmacological studies designed, and ethical issues addressed? METHOD: Experts from key stakeholder communities, including academic clinicians, researchers, practicing clinicians, U.S. Food and Drug Administration, National Institute of Mental Health, industry sponsors, and patient and family advocates, met for a 2-day consensus conference on November 4 and 5, 2004. After evaluating summary presentations on current research evidence, participants were assigned to three workgroups, examined core issues, and generated consensus guidelines in their areas. Workgroup recommendations were discussed by the whole group to reach consensus, and then further iterated and condensed into this report postconference by the authors. RESULTS: Conference participants agreed that IA is a substantial public health and clinical concern, constitutes a key therapeutic target across multiple disorders, and can be measured with sufficient precision that pharmacological studies are warranted. Additional areas of consensus concerned types of measures, optimal study designs, and ethical imperatives. CONCLUSION: Derived from scientific evidence and clinical experience, these consensus-driven recommendations can guide the design of future studies. Copyright 2007
AB - OBJECTIVE: To determine whether impulsive aggression (IA) is a meaningful clinical construct and to ascertain whether it is sufficiently similar across diagnostic categories, such that parallel studies across disorders might constitute appropriate evidence for pursuing indications. If so, how should IA be assessed, pharmacological studies designed, and ethical issues addressed? METHOD: Experts from key stakeholder communities, including academic clinicians, researchers, practicing clinicians, U.S. Food and Drug Administration, National Institute of Mental Health, industry sponsors, and patient and family advocates, met for a 2-day consensus conference on November 4 and 5, 2004. After evaluating summary presentations on current research evidence, participants were assigned to three workgroups, examined core issues, and generated consensus guidelines in their areas. Workgroup recommendations were discussed by the whole group to reach consensus, and then further iterated and condensed into this report postconference by the authors. RESULTS: Conference participants agreed that IA is a substantial public health and clinical concern, constitutes a key therapeutic target across multiple disorders, and can be measured with sufficient precision that pharmacological studies are warranted. Additional areas of consensus concerned types of measures, optimal study designs, and ethical imperatives. CONCLUSION: Derived from scientific evidence and clinical experience, these consensus-driven recommendations can guide the design of future studies. Copyright 2007
KW - Aggression
KW - Assessment ethics
KW - Clinical trials
KW - Impulsivity
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UR - http://www.scopus.com/inward/citedby.url?scp=33847187345&partnerID=8YFLogxK
U2 - 10.1097/chi.0b013e31802f1454
DO - 10.1097/chi.0b013e31802f1454
M3 - Article
C2 - 17314717
AN - SCOPUS:33847187345
SN - 0890-8567
VL - 46
SP - 309
EP - 322
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 3
ER -