Concurrent eosinophilic fasciitis and cutaneous T-cell lymphoma: Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malignant neoplasms?

L. S. Chan, C. A. Hanson, K. D. Cooper

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Eosinophilic fasciitis has been reported to precede hematologic malignant neoplasms such as myelomonocytic leukemia, lymphocytic leukemia, and Hodgkin's lymphoma. In this case study, eosinophilic fasciitis occurred concurrently with cutaneous T-cell lymphoma (mycosis fungoides). The clinical diagnosis of eosinophilic fasciitis was based on painful sclerodermatous lesions on the extremities and trunk without acrosclerosis. There was histologic confirmation with edema and lymphocytic inflammation in the superficial muscular fascia and dermis. Deposition of immune reactants was found in the fascia and dermis. In addition, peripheral eosinophilia and circulating immune complexes were detected. The diagnosis of cutaneous T-cell lymphoma (mycosis fungoides) was based on extensive erythematous cutaneous plaques, dermal and epidermal lymphocytic atypia, loss of pan-T-cell immunologic markers, and a cutaneous lesional T-cell receptor β-chain rearrangement by Southern blot analysis. Eosinophilic fasciitis may occur as a paraneoplastic syndrome associated with hematologic malignant neoplasms, including mycosis fungoides. Cytokines or lymphokines released by activated immunocytes, either malignant leukocytes or normal leukocytes reacting to malignant cells, may be responsible for the eosinophilia and sclerosis seen in these associated hematologic malignant neoplasms.

Original languageEnglish (US)
Pages (from-to)862-865
Number of pages4
JournalArchives of Dermatology
Volume127
Issue number6
DOIs
StatePublished - 1991
Externally publishedYes

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Paraneoplastic Syndromes
Cutaneous T-Cell Lymphoma
Mycosis Fungoides
Hematologic Neoplasms
T-Lymphocytes
Eosinophilia
Dermis
Skin
Neoplasms
Leukocytes
Lymphoid Leukemia
Lymphokines
Fascia
Subcutaneous Tissue
Sclerosis
B-Cell Chronic Lymphocytic Leukemia
T-Cell Antigen Receptor
Southern Blotting
Antigen-Antibody Complex
Hodgkin Disease

ASJC Scopus subject areas

  • Dermatology

Cite this

Concurrent eosinophilic fasciitis and cutaneous T-cell lymphoma : Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malignant neoplasms? / Chan, L. S.; Hanson, C. A.; Cooper, K. D.

In: Archives of Dermatology, Vol. 127, No. 6, 1991, p. 862-865.

Research output: Contribution to journalArticle

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