TY - JOUR
T1 - Comprehensive assessment of gastric emptying with a stable isotope breath test
AU - Bharucha, A. E.
AU - Camilleri, M.
AU - Veil, E.
AU - Burton, D.
AU - Zinsmeister, A. R.
PY - 2013/1
Y1 - 2013/1
N2 - Background The [13C]-Spirulina platensis gastric emptying breath test (GEBT) with five samples is accurate relative to scintigraphy. This study was primarily designed to further validate this GEBT using a slightly different process for incorporating [13C] in Spirulina and to evaluate the utility of additional samples for assessing early gastric emptying. Methods After a 223kcal, test meal labeled with 99mTc and [13C]-S. platensis, scintigraphic images, and five breath samples (45, 90, 120, 180, and 240min, GEBT5) were collected in 14 controls (Part A). In Part B, nine breath samples were collected at 15, 30, 45, 60, 90, 120, 150, 180, and 240min (GEBT9) in 30 subjects (15 controls, 15 dyspepsia). Using correlation between [13C] breath excretion and scintigraphic emptying, lag time (t10, time for 10% emptying), emptying at 30min (GE30), and half time (t50) were estimated for GEBT5 (Parts A and B) and GEBT9 (Part B). Key Results Half time values for scintigraphy, GEBT5, and GEBT9 were highly concordant. t10 by GEBT9 (90%CI, 6-15min) was more strongly correlated [CCC 0.80 (95% CI, 0.63-0.90)] with scintigraphy (90% CI, 5-12min), than GEBT5 [10-19min, CCC 0.73 (95% CI, 0.54-0.85)]. The correlation between estimated values (GEBT9) and linearly interpolated values (GEBT5) was closer at 60 [CCC 0.95 (95% CI, 0.91-0.97)] than 30min [CCC 0.81 (95% CI, 0.71-0.89)]. Conclusions & Inferences The [13C]-S. platensis GEBT can accurately measure GE. While 5- and 9-samples are equally accurate for measuring t50, GEBT9 provides a more comprehensive assessment of early GE (t10 and GE30).
AB - Background The [13C]-Spirulina platensis gastric emptying breath test (GEBT) with five samples is accurate relative to scintigraphy. This study was primarily designed to further validate this GEBT using a slightly different process for incorporating [13C] in Spirulina and to evaluate the utility of additional samples for assessing early gastric emptying. Methods After a 223kcal, test meal labeled with 99mTc and [13C]-S. platensis, scintigraphic images, and five breath samples (45, 90, 120, 180, and 240min, GEBT5) were collected in 14 controls (Part A). In Part B, nine breath samples were collected at 15, 30, 45, 60, 90, 120, 150, 180, and 240min (GEBT9) in 30 subjects (15 controls, 15 dyspepsia). Using correlation between [13C] breath excretion and scintigraphic emptying, lag time (t10, time for 10% emptying), emptying at 30min (GE30), and half time (t50) were estimated for GEBT5 (Parts A and B) and GEBT9 (Part B). Key Results Half time values for scintigraphy, GEBT5, and GEBT9 were highly concordant. t10 by GEBT9 (90%CI, 6-15min) was more strongly correlated [CCC 0.80 (95% CI, 0.63-0.90)] with scintigraphy (90% CI, 5-12min), than GEBT5 [10-19min, CCC 0.73 (95% CI, 0.54-0.85)]. The correlation between estimated values (GEBT9) and linearly interpolated values (GEBT5) was closer at 60 [CCC 0.95 (95% CI, 0.91-0.97)] than 30min [CCC 0.81 (95% CI, 0.71-0.89)]. Conclusions & Inferences The [13C]-S. platensis GEBT can accurately measure GE. While 5- and 9-samples are equally accurate for measuring t50, GEBT9 provides a more comprehensive assessment of early GE (t10 and GE30).
KW - Breath test
KW - Dumping
KW - Dyspepsia
KW - Gastric emptying
KW - Gastroparesis
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U2 - 10.1111/nmo.12054
DO - 10.1111/nmo.12054
M3 - Article
C2 - 23216872
AN - SCOPUS:84871649374
SN - 1350-1925
VL - 25
SP - e60-e69
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
IS - 1
ER -