Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery

Xifeng Liu, Kevin A. Fundora, Zifei Zhou, Alan Lee Miller, Lichun Lu

Research output: Contribution to journalArticle

Abstract

Current delivery of chemotherapy drugs to osteosarcoma is limited by the difficulties in overcoming the solid tumor microenvironment and the cardiotoxicity of doxorubicin (DOX). In previous work we found that phase separation could generate microspheres with high porosity. In this study, we applied these phase-separated porous microspheres as carriers for long-term anticancer drug delivery. Novel poly(propylene fumarate)-co-poly(l-lactic acid) microspheres incorporating DOX were fabricated by thermally induced phase separation. Following embedding into oligo(poly[ethylene glycol] fumarate) hydrogel, the composite system showed prolonged and pH-responsive release of DOX. In vitro cytotoxicity study using osteosarcoma 143B cells showed substantial long-term cytotoxic effects for up to 30 days. As a result, the DOX drug delivery hydrogel developed in this work may have significant potential as a long-term and localized chemotherapy device that would be sensitive to the acidic microenvironment of osteosarcoma and other cancers. A composite hydrogel embedded with porous microspheres fabricated by phase separation methods was developed and showed excellent long-term anticancer drug delivery capability to cancer cells.

Original languageEnglish (US)
Pages (from-to)172-182
Number of pages11
JournalTissue Engineering - Part A
Volume25
Issue number3-4
DOIs
StatePublished - Feb 1 2019
Externally publishedYes

Fingerprint

Hydrogel
Microspheres
Drug delivery
Hydrogels
Doxorubicin
Osteosarcoma
Phase separation
Chemotherapy
Composite materials
Pharmaceutical Preparations
Drug Therapy
Tumor Microenvironment
Porosity
Lactic acid
Cytotoxicity
Polyethylene glycols
Large scale systems
Tumors
Polypropylenes
Lactic Acid

Keywords

  • cancer
  • drug delivery
  • hydrogel
  • osteosarcoma
  • porous microspheres

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

Cite this

Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery. / Liu, Xifeng; Fundora, Kevin A.; Zhou, Zifei; Miller, Alan Lee; Lu, Lichun.

In: Tissue Engineering - Part A, Vol. 25, No. 3-4, 01.02.2019, p. 172-182.

Research output: Contribution to journalArticle

Liu, Xifeng ; Fundora, Kevin A. ; Zhou, Zifei ; Miller, Alan Lee ; Lu, Lichun. / Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery. In: Tissue Engineering - Part A. 2019 ; Vol. 25, No. 3-4. pp. 172-182.
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