Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs

S. Teyssen, E. Niebergall-Roth, A. Rausch, C. Beglinger, R. L. Riepl, Suresh T Chari, M. V. Singer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In six conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses (20.25 to 81.0 nmol/kg/h) of the muscarinic M1-receptor antagonist telenzepine, the cholecystokinin (CCK) antagonist loxiglumide (2.5 to 10.0 mg/kg/h) and several combinations of both drugs on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37-10,0 mmol/h) given against a background of secretin (20.5 pmol/kg/h i.v.). Except for 20.25 nmol/kg/h telenzepine, all tested doses of telenzepine and/or loxiglumide decreased the 180-min integrated bicarbonate response to tryptophan by 55 to 119%. Except of 20.25 nmol/kg/h telenzepine and/or 2.5 mg/kg/h loxiglumide, all tested doses of telenzepine and/or loxiglumide inhibited the tryptophan stimulated integrated pancreatic protein response by 54 to 88%. While telenzepine mainly inhibited the bicarbonate and protein response to the lower loads of tryptophan (0.37- 1.1 mmol/h), loxiglumide decreased the response to all loads of tryptophan. The inhibition evoked by the combinations of telenzepine and loxiglumide was not significantly greater than that by single infusion of either drug. The CCK plasma levels basally and in response to tryptophan were not significantly altered by telenzepine and/or loxiglumide. These findings indicate that (1) both enteropancreatic cholinergic reflexes and the hormone CCK are mediators of the protein response to intraduodenal tryptophan, (2) enteropancreatic cholinergic reflexes are probably the dominant mediators of the response to low amounts of tryptophan, whereas CCK is the major mediator of the response to high loads of tryptophan, (3) the two mediators seem to act independently of each other, and (4) the release of CCK by intestinal tryptophan is not influenced by telenzepine or loxiglumide.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalPancreas
Volume13
Issue number4
StatePublished - 1996
Externally publishedYes

Fingerprint

Cholecystokinin Receptors
Tryptophan
Dogs
Cholecystokinin
Bicarbonates
Cholinergic Agents
Reflex
Tetragastrin
loxiglumide
telenzepine
Gastric Fistula
Muscarinic M1 Receptors
Pancreatic Fistula
Proteins
Secretin
Drug Combinations
Perfusion
Hormones

Keywords

  • Cholecystokinin
  • Dogs
  • Loxiglumide
  • Pancreatic secretion
  • Telenzepine
  • Tryptophan

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Teyssen, S., Niebergall-Roth, E., Rausch, A., Beglinger, C., Riepl, R. L., Chari, S. T., & Singer, M. V. (1996). Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs. Pancreas, 13(4), 407-416.

Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs. / Teyssen, S.; Niebergall-Roth, E.; Rausch, A.; Beglinger, C.; Riepl, R. L.; Chari, Suresh T; Singer, M. V.

In: Pancreas, Vol. 13, No. 4, 1996, p. 407-416.

Research output: Contribution to journalArticle

Teyssen, S, Niebergall-Roth, E, Rausch, A, Beglinger, C, Riepl, RL, Chari, ST & Singer, MV 1996, 'Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs', Pancreas, vol. 13, no. 4, pp. 407-416.
Teyssen, S. ; Niebergall-Roth, E. ; Rausch, A. ; Beglinger, C. ; Riepl, R. L. ; Chari, Suresh T ; Singer, M. V. / Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs. In: Pancreas. 1996 ; Vol. 13, No. 4. pp. 407-416.
@article{46a9b11324984651b005429622241800,
title = "Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs",
abstract = "In six conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses (20.25 to 81.0 nmol/kg/h) of the muscarinic M1-receptor antagonist telenzepine, the cholecystokinin (CCK) antagonist loxiglumide (2.5 to 10.0 mg/kg/h) and several combinations of both drugs on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37-10,0 mmol/h) given against a background of secretin (20.5 pmol/kg/h i.v.). Except for 20.25 nmol/kg/h telenzepine, all tested doses of telenzepine and/or loxiglumide decreased the 180-min integrated bicarbonate response to tryptophan by 55 to 119{\%}. Except of 20.25 nmol/kg/h telenzepine and/or 2.5 mg/kg/h loxiglumide, all tested doses of telenzepine and/or loxiglumide inhibited the tryptophan stimulated integrated pancreatic protein response by 54 to 88{\%}. While telenzepine mainly inhibited the bicarbonate and protein response to the lower loads of tryptophan (0.37- 1.1 mmol/h), loxiglumide decreased the response to all loads of tryptophan. The inhibition evoked by the combinations of telenzepine and loxiglumide was not significantly greater than that by single infusion of either drug. The CCK plasma levels basally and in response to tryptophan were not significantly altered by telenzepine and/or loxiglumide. These findings indicate that (1) both enteropancreatic cholinergic reflexes and the hormone CCK are mediators of the protein response to intraduodenal tryptophan, (2) enteropancreatic cholinergic reflexes are probably the dominant mediators of the response to low amounts of tryptophan, whereas CCK is the major mediator of the response to high loads of tryptophan, (3) the two mediators seem to act independently of each other, and (4) the release of CCK by intestinal tryptophan is not influenced by telenzepine or loxiglumide.",
keywords = "Cholecystokinin, Dogs, Loxiglumide, Pancreatic secretion, Telenzepine, Tryptophan",
author = "S. Teyssen and E. Niebergall-Roth and A. Rausch and C. Beglinger and Riepl, {R. L.} and Chari, {Suresh T} and Singer, {M. V.}",
year = "1996",
language = "English (US)",
volume = "13",
pages = "407--416",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs

AU - Teyssen, S.

AU - Niebergall-Roth, E.

AU - Rausch, A.

AU - Beglinger, C.

AU - Riepl, R. L.

AU - Chari, Suresh T

AU - Singer, M. V.

PY - 1996

Y1 - 1996

N2 - In six conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses (20.25 to 81.0 nmol/kg/h) of the muscarinic M1-receptor antagonist telenzepine, the cholecystokinin (CCK) antagonist loxiglumide (2.5 to 10.0 mg/kg/h) and several combinations of both drugs on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37-10,0 mmol/h) given against a background of secretin (20.5 pmol/kg/h i.v.). Except for 20.25 nmol/kg/h telenzepine, all tested doses of telenzepine and/or loxiglumide decreased the 180-min integrated bicarbonate response to tryptophan by 55 to 119%. Except of 20.25 nmol/kg/h telenzepine and/or 2.5 mg/kg/h loxiglumide, all tested doses of telenzepine and/or loxiglumide inhibited the tryptophan stimulated integrated pancreatic protein response by 54 to 88%. While telenzepine mainly inhibited the bicarbonate and protein response to the lower loads of tryptophan (0.37- 1.1 mmol/h), loxiglumide decreased the response to all loads of tryptophan. The inhibition evoked by the combinations of telenzepine and loxiglumide was not significantly greater than that by single infusion of either drug. The CCK plasma levels basally and in response to tryptophan were not significantly altered by telenzepine and/or loxiglumide. These findings indicate that (1) both enteropancreatic cholinergic reflexes and the hormone CCK are mediators of the protein response to intraduodenal tryptophan, (2) enteropancreatic cholinergic reflexes are probably the dominant mediators of the response to low amounts of tryptophan, whereas CCK is the major mediator of the response to high loads of tryptophan, (3) the two mediators seem to act independently of each other, and (4) the release of CCK by intestinal tryptophan is not influenced by telenzepine or loxiglumide.

AB - In six conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses (20.25 to 81.0 nmol/kg/h) of the muscarinic M1-receptor antagonist telenzepine, the cholecystokinin (CCK) antagonist loxiglumide (2.5 to 10.0 mg/kg/h) and several combinations of both drugs on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37-10,0 mmol/h) given against a background of secretin (20.5 pmol/kg/h i.v.). Except for 20.25 nmol/kg/h telenzepine, all tested doses of telenzepine and/or loxiglumide decreased the 180-min integrated bicarbonate response to tryptophan by 55 to 119%. Except of 20.25 nmol/kg/h telenzepine and/or 2.5 mg/kg/h loxiglumide, all tested doses of telenzepine and/or loxiglumide inhibited the tryptophan stimulated integrated pancreatic protein response by 54 to 88%. While telenzepine mainly inhibited the bicarbonate and protein response to the lower loads of tryptophan (0.37- 1.1 mmol/h), loxiglumide decreased the response to all loads of tryptophan. The inhibition evoked by the combinations of telenzepine and loxiglumide was not significantly greater than that by single infusion of either drug. The CCK plasma levels basally and in response to tryptophan were not significantly altered by telenzepine and/or loxiglumide. These findings indicate that (1) both enteropancreatic cholinergic reflexes and the hormone CCK are mediators of the protein response to intraduodenal tryptophan, (2) enteropancreatic cholinergic reflexes are probably the dominant mediators of the response to low amounts of tryptophan, whereas CCK is the major mediator of the response to high loads of tryptophan, (3) the two mediators seem to act independently of each other, and (4) the release of CCK by intestinal tryptophan is not influenced by telenzepine or loxiglumide.

KW - Cholecystokinin

KW - Dogs

KW - Loxiglumide

KW - Pancreatic secretion

KW - Telenzepine

KW - Tryptophan

UR - http://www.scopus.com/inward/record.url?scp=0029658082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029658082&partnerID=8YFLogxK

M3 - Article

C2 - 8899802

AN - SCOPUS:0029658082

VL - 13

SP - 407

EP - 416

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 4

ER -