Comparison of regional myocardial blood flow and metabolism distal to a critical coronary stenosis in the fibrillating heart during alternate periods of pulsatile and nonpulsatile perfusion

R. C. Ciardullo, Hartzell V Schaff, J. T. Flaherty, J. S. Donahoo, V. L. Gott

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Abstract

The effect of pulsatile cardiopulmonary bypass on intramyocardial gas tensions and regional myocardial blood flow was studied in 10 mongrel dogs. Following application of a critical stenosis to the circumflex coronary artery (CIRC), animals were placed on total bypass with vented, fibrillating hearts. During three 45 minute periods of perfusion, animals alternately received pulsatile or linear flow with perfusion pressure carefully maintained at 80 mm Hg. In myocardium supplied by the stenosed CIRC, intramyocardial oxygen tension (pO 2) rose from 13 ± 3 to 19 ± 5 mm. Hg when a period of linear flow was followed by a period of pulsatile flow (p < 0.025). Similarly in the CIRC-supplied area, intramyocardial carbon dioxide (pCO 2) decreased from 128 ± 12 to 99 ± 12 mm. Hg (p < 0.005) with conversion from linear to pulsatile flow. Myocardial blood flow (microsphere technique) to endocardial and epicardial layers of the CIRC-supplied area was significantly greater (p < 0.05) during pulsatile than during linear perfusion. In contrast, when periods of pulsatile bypass were followed by periods of linear perfusion, myocardial pO 2 fell from 25 ± 6 to 9 ± 3 (p < 0.02) and myocardial pCO 2 rose from 82 ± 12 to 154 ± 12 mm. Hg (p < 0.001). These data suggest that (1) fibrillation-induced regional ischemia distal to a critical coronary stenosis can be reduced by pulsatile perfusion during bypass and (2) the mechanism for the reduction in regional ischemia is improved myocardial blood flow.

Original languageEnglish (US)
Pages (from-to)193-205
Number of pages13
JournalJournal of Thoracic and Cardiovascular Surgery
Volume75
Issue number2
StatePublished - 1978
Externally publishedYes

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Pulsatile Flow
Coronary Stenosis
Regional Blood Flow
Coronary Vessels
Perfusion
Ischemia
Cardiopulmonary Bypass
Microspheres
Carbon Dioxide
Myocardium
Pathologic Constriction
Gases
Dogs
Oxygen
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

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title = "Comparison of regional myocardial blood flow and metabolism distal to a critical coronary stenosis in the fibrillating heart during alternate periods of pulsatile and nonpulsatile perfusion",
abstract = "The effect of pulsatile cardiopulmonary bypass on intramyocardial gas tensions and regional myocardial blood flow was studied in 10 mongrel dogs. Following application of a critical stenosis to the circumflex coronary artery (CIRC), animals were placed on total bypass with vented, fibrillating hearts. During three 45 minute periods of perfusion, animals alternately received pulsatile or linear flow with perfusion pressure carefully maintained at 80 mm Hg. In myocardium supplied by the stenosed CIRC, intramyocardial oxygen tension (pO 2) rose from 13 ± 3 to 19 ± 5 mm. Hg when a period of linear flow was followed by a period of pulsatile flow (p < 0.025). Similarly in the CIRC-supplied area, intramyocardial carbon dioxide (pCO 2) decreased from 128 ± 12 to 99 ± 12 mm. Hg (p < 0.005) with conversion from linear to pulsatile flow. Myocardial blood flow (microsphere technique) to endocardial and epicardial layers of the CIRC-supplied area was significantly greater (p < 0.05) during pulsatile than during linear perfusion. In contrast, when periods of pulsatile bypass were followed by periods of linear perfusion, myocardial pO 2 fell from 25 ± 6 to 9 ± 3 (p < 0.02) and myocardial pCO 2 rose from 82 ± 12 to 154 ± 12 mm. Hg (p < 0.001). These data suggest that (1) fibrillation-induced regional ischemia distal to a critical coronary stenosis can be reduced by pulsatile perfusion during bypass and (2) the mechanism for the reduction in regional ischemia is improved myocardial blood flow.",
author = "Ciardullo, {R. C.} and Schaff, {Hartzell V} and Flaherty, {J. T.} and Donahoo, {J. S.} and Gott, {V. L.}",
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T1 - Comparison of regional myocardial blood flow and metabolism distal to a critical coronary stenosis in the fibrillating heart during alternate periods of pulsatile and nonpulsatile perfusion

AU - Ciardullo, R. C.

AU - Schaff, Hartzell V

AU - Flaherty, J. T.

AU - Donahoo, J. S.

AU - Gott, V. L.

PY - 1978

Y1 - 1978

N2 - The effect of pulsatile cardiopulmonary bypass on intramyocardial gas tensions and regional myocardial blood flow was studied in 10 mongrel dogs. Following application of a critical stenosis to the circumflex coronary artery (CIRC), animals were placed on total bypass with vented, fibrillating hearts. During three 45 minute periods of perfusion, animals alternately received pulsatile or linear flow with perfusion pressure carefully maintained at 80 mm Hg. In myocardium supplied by the stenosed CIRC, intramyocardial oxygen tension (pO 2) rose from 13 ± 3 to 19 ± 5 mm. Hg when a period of linear flow was followed by a period of pulsatile flow (p < 0.025). Similarly in the CIRC-supplied area, intramyocardial carbon dioxide (pCO 2) decreased from 128 ± 12 to 99 ± 12 mm. Hg (p < 0.005) with conversion from linear to pulsatile flow. Myocardial blood flow (microsphere technique) to endocardial and epicardial layers of the CIRC-supplied area was significantly greater (p < 0.05) during pulsatile than during linear perfusion. In contrast, when periods of pulsatile bypass were followed by periods of linear perfusion, myocardial pO 2 fell from 25 ± 6 to 9 ± 3 (p < 0.02) and myocardial pCO 2 rose from 82 ± 12 to 154 ± 12 mm. Hg (p < 0.001). These data suggest that (1) fibrillation-induced regional ischemia distal to a critical coronary stenosis can be reduced by pulsatile perfusion during bypass and (2) the mechanism for the reduction in regional ischemia is improved myocardial blood flow.

AB - The effect of pulsatile cardiopulmonary bypass on intramyocardial gas tensions and regional myocardial blood flow was studied in 10 mongrel dogs. Following application of a critical stenosis to the circumflex coronary artery (CIRC), animals were placed on total bypass with vented, fibrillating hearts. During three 45 minute periods of perfusion, animals alternately received pulsatile or linear flow with perfusion pressure carefully maintained at 80 mm Hg. In myocardium supplied by the stenosed CIRC, intramyocardial oxygen tension (pO 2) rose from 13 ± 3 to 19 ± 5 mm. Hg when a period of linear flow was followed by a period of pulsatile flow (p < 0.025). Similarly in the CIRC-supplied area, intramyocardial carbon dioxide (pCO 2) decreased from 128 ± 12 to 99 ± 12 mm. Hg (p < 0.005) with conversion from linear to pulsatile flow. Myocardial blood flow (microsphere technique) to endocardial and epicardial layers of the CIRC-supplied area was significantly greater (p < 0.05) during pulsatile than during linear perfusion. In contrast, when periods of pulsatile bypass were followed by periods of linear perfusion, myocardial pO 2 fell from 25 ± 6 to 9 ± 3 (p < 0.02) and myocardial pCO 2 rose from 82 ± 12 to 154 ± 12 mm. Hg (p < 0.001). These data suggest that (1) fibrillation-induced regional ischemia distal to a critical coronary stenosis can be reduced by pulsatile perfusion during bypass and (2) the mechanism for the reduction in regional ischemia is improved myocardial blood flow.

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